Seroatlas · Human Serome Atlas

RPE

Ribulose-phosphate 3-epimerase

Also known as: RPE_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96AT9
Gene: RPE
Ensembl: ENSG00000197713
Chromosome: 2
Canonical length: 228 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables D-ribulose-phosphate 3-epimerase activity; metal ion binding activity; and protein homodimerization activity. Involved in carbohydrate metabolic process and pentose-phosphate shunt. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

228 residues, UniProt reviewed canonical sequence.

>Q96AT9|RPE
     1  MASGCKIGPS ILNSDLANLG AECLRMLDSG ADYLHLDVMD GHFVPNITFG HPVVESLRKQ
    61  LGQDPFFDMH MMVSKPEQWV KPMAVAGANQ YTFHLEATEN PGALIKDIRE NGMKVGLAIK
   121  PGTSVEYLAP WANQIDMALV MTVEPGFGGQ KFMEDMMPKV HWLRTQFPSL DIEVDGGVGP
   181  DTVHKCAEAG ANMIVSGSAI MRSEDPRSVI NLLRNVCSEA AQKRSLDR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPE can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.23
Highest tissue expression: 30 nTPM

Expression across tissuesHPA

Tissue

rectum: 30 nTPM
seminal vesicle: 29 nTPM
kidney: 28 nTPM
placenta: 28 nTPM
thyroid gland: 28 nTPM
tonsil: 28 nTPM

Single-cell type

neutrophil progenitors: 103 nCPM
monocyte progenitors: 60 nCPM
nk-cells: 58 nCPM
corticotrophs: 58 nCPM
brain excitatory neurons: 57 nCPM
brain inhibitory neurons: 57 nCPM

Immune cell

NK-cell: 77 nTPM
myeloid DC: 70 nTPM
intermediate monocyte: 51 nTPM
classical monocyte: 40 nTPM
non-classical monocyte: 35 nTPM
total PBMC: 29 nTPM

Brain region

white matter: 70 nTPM
cerebral cortex: 67 nTPM
basal ganglia: 65 nTPM
cerebellum: 62 nTPM
thalamus: 57 nTPM
hypothalamus: 55 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.21
gnomAD pLI: 0
gnomAD missense Z: 0.52
DepMap mean gene effect: -0.62
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPE as an antibody target. Whether an autoantibody or antibody against RPE could matter depends on whether native RPE is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPE is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPE as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...