RPAIN
RPA-interacting protein
Also known as: hRIP, MGC4189, RIP, RIP_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q86UA6
- Gene
- RPAIN
- Ensembl
- ENSG00000129197
- Chromosome
- 17
- Canonical length
- 219 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Nucleoli fibrillar center
OverviewNCBI Gene
Predicted to enable zinc ion binding activity. Acts upstream of or within protein import into nucleus and response to UV. Located in PML body; cytoplasm; and fibrillar center. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
219 residues, UniProt reviewed canonical sequence.
>Q86UA6|RPAIN
1 MAESLRSPRR SLYKLVGSPP WKEAFRQRCL ERMRNSRDRL LNRYRQAGSS GPGNSQNSFL
61 VQEVMEEEWN ALQSVENCPE DLAQLEELID MAVLEEIQQE LINQEQSIIS EYEKSLQFDE
121 KCLSIMLAEW EANPLICPVC TKYNLRITSG VVVCQCGLSI PSHSSELTEQ KLRACLEGSI
181 NEHSAHCPHT PEFSVTGGTE EKSSLLMSCL ACDTWAVILLocalizationUniProt · AlphaFold · HPA
Whether an antibody against RPAIN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.46
- Highest tissue expression
- 50 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 50 nTPM
- choroid plexus: 39 nTPM
- tongue: 36 nTPM
- thymus: 33 nTPM
- amygdala: 32 nTPM
- heart muscle: 31 nTPM
Single-cell type
- endometrial glandular cells: 176 nCPM
- ocular epithelial cells: 141 nCPM
- endometrial luminal cells: 139 nCPM
- granulosa cells: 127 nCPM
- urothelial cells: 125 nCPM
- esophageal suprabasal cells: 123 nCPM
Immune cell
- memory B-cell: 76 nTPM
- T-reg: 63 nTPM
- eosinophil: 59 nTPM
- naive B-cell: 57 nTPM
- plasmacytoid DC: 56 nTPM
- naive CD4 T-cell: 53 nTPM
Brain region
- hypothalamus: 14 nTPM
- white matter: 14 nTPM
- pons: 13 nTPM
- cerebral cortex: 13 nTPM
- hippocampal formation: 12 nTPM
- medulla oblongata: 12 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.84
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.14
- DepMap mean gene effect
- -1.11
- DepMap dependency class
- common
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- RPA-interacting protein, central domain
- RPA-interacting protein
- RPA-interacting protein, N-terminal domain
- RPA-interacting protein, C-terminal domain
- Replication protein A interacting N-terminal
- Replication protein A interacting middle
- Replication protein A interacting C-terminal
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads RPAIN as an antibody target. Whether an autoantibody or antibody against RPAIN could matter depends on whether native RPAIN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
RPAIN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label RPAIN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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