ROMO1

Protein identityUniProt · HPA

UniProt accession

P60602

Gene

ROMO1

Ensembl

ENSG00000125995

Chromosome

20

Canonical length

79 aa

Protein class

Predicted intracellular proteins, Transporters

OverviewNCBI Gene

The protein encoded by this gene is a mitochondrial membrane protein that is responsible for increasing the level of reactive oxygen species (ROS) in cells. The protein also has antimicrobial activity against a variety of bacteria by inducing bacterial membrane breakage. [provided by RefSeq, Nov 2014]

Canonical amino-acid sequenceUniProt

79 residues, UniProt reviewed canonical sequence.

>P60602|ROMO1
     1  MPVAVGPYGQ SQPSCFDRVK MGFVMGCAVG MAAGALFGTF SCLRIGMRGR ELMGGIGKTM
    61  MQSGGTFGTF MAIGMGIRC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ROMO1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Other membrane

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.43

Highest tissue expression

331 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.4

gnomAD pLI

0.23

gnomAD missense Z

1.09

DepMap mean gene effect

-1.02

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• antimicrobial humoral immune response mediated by antimicrobial peptide
• cellular response to reactive oxygen species
• cytolysis by host of symbiont cells
• defense response to bacterium
• defense response to Gram-negative bacterium
• defense response to Gram-positive bacterium
• intracellular protein transport
• killing of cells of another organism
• monoatomic cation transmembrane transport
• positive regulation of reactive oxygen species metabolic process
• protein import into mitochondrial matrix
• protein insertion into mitochondrial inner membrane
• replicative senescence

Molecular functions

• monoatomic cation transmembrane transporter activity

Cellular components

• mitochondrial inner membrane
• mitochondrion
• TIM23 mitochondrial import inner membrane translocase complex

Protein domainsUniProt · Pfam · InterPro

• Romo1/Mgr2
• Reactive mitochondrial oxygen species modulator 1

KeywordsUniProt

• Antibiotic
• Antimicrobial
• Membrane
• Mitochondrion
• Mitochondrion inner membrane
• Transmembrane
• Transmembrane helix