Seroatlas · Human Serome Atlas

ROGDI

Protein rogdi homolog

Also known as: FLJ22386, RAV2, ROGD1, ROGDI_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9GZN7
Gene: ROGDI
Ensembl: ENSG00000067836
Chromosome: 16
Canonical length: 287 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

Involved in brain development; neurogenesis; and odontogenesis of dentin-containing tooth. Located in nuclear envelope. Implicated in Kohlschutter-Tonz syndrome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

287 residues, UniProt reviewed canonical sequence.

>Q9GZN7|ROGDI
     1  MATVMAATAA ERAVLEEEFR WLLHDEVHAV LKQLQDILKE ASLRFTLPGS GTEGPAKQEN
    61  FILGSCGTDQ VKGVLTLQGD ALSQADVNLK MPRNNQLLHF AFREDKQWKL QQIQDARNHV
   121  SQAIYLLTSR DQSYQFKTGA EVLKLMDAVM LQLTRARNRL TTPATLTLPE IAASGLTRMF
   181  APALPSDLLV NVYINLNKLC LTVYQLHALQ PNSTKNFRPA GGAVLHSPGA MFEWGSQRLE
   241  VSHVHKVECV IPWLNDALVY FTVSLQLCQQ LKDKISVFSS YWSYRPF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ROGDI can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 96 nTPM

Expression across tissuesHPA

Tissue

hippocampal formation: 96 nTPM
cerebral cortex: 90 nTPM
basal ganglia: 87 nTPM
spinal cord: 86 nTPM
heart muscle: 80 nTPM
cerebellum: 80 nTPM

Single-cell type

oligodendrocytes: 95 nCPM
brain excitatory neurons: 44 nCPM
brain inhibitory neurons: 33 nCPM
other brain neurons: 31 nCPM
astrocytes: 21 nCPM
ependymal cells: 18 nCPM

Immune cell

classical monocyte: 75 nTPM
intermediate monocyte: 63 nTPM
non-classical monocyte: 62 nTPM
myeloid DC: 62 nTPM
total PBMC: 38 nTPM
plasmacytoid DC: 35 nTPM

Brain region

cerebral cortex: 114 nTPM
white matter: 97 nTPM
thalamus: 96 nTPM
hippocampal formation: 86 nTPM
midbrain: 73 nTPM
medulla oblongata: 71 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ROGDI.

Disease | AllUniProt

Conditions ROGDI is implicated in, by any mechanism.

Kohlschuetter-Toenz syndrome (KTZS) MIM:226750

Disease | GeneticClinVar

49 pathogenic / likely-pathogenic of 651 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Amelocerebrohypohidrotic syndrome
Gastric cancer

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.42
gnomAD pLI: 0
gnomAD missense Z: -1.32
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

RAVE subunit 2/Rogdi
Rogdi leucine zipper containing protein

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ROGDI as an antibody target. Whether an autoantibody or antibody against ROGDI could matter depends on whether native ROGDI is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ROGDI is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ROGDI as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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