Seroatlas · Human Serome Atlas

RNPEPL1

Aminopeptidase RNPEPL1

Also known as: RNPL1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HAU8
Gene: RNPEPL1
Ensembl: ENSG00000142327
Chromosome: 2
Canonical length: 725 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

Enables metalloaminopeptidase activity. Involved in proteolysis. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

725 residues, UniProt reviewed canonical sequence.

>Q9HAU8|RNPEPL1
     1  MAAQCCCRQA PGAEAAPVRP PPEPPPALDV ASASSAQLFR LRHLQLGLEL RPEARELAGC
    61  LVLELCALRP APRALVLDAH PALRLHSAAF RRAPAAAAET PCAFAFSAPG PGPAPPPPLP
   121  AFPEAPGSEP ACCPLAFRVD PFTDYGSSLT VTLPPELQAH QPFQVILRYT STDAPAIWWL
   181  DPELTYGCAK PFVFTQGHSV CNRSFFPCFD TPAVKCTYSA VVKAPSGVQV LMSATRSAYM
   241  EEEGVFHFHM EHPVPAYLVA LVAGDLKPAD IGPRSRVWAE PCLLPTATSK LSGAVEQWLS
   301  AAERLYGPYM WGRYDIVFLP PSFPIVAMEN PCLTFIISSI LESDEFLVID VIHEVAHSWF
   361  GNAVTNATWE EMWLSEGLAT YAQRRITTET YGAAFTCLET AFRLDALHRQ MKLLGEDSPV
   421  SKLQVKLEPG VNPSHLMNLF TYEKGYCFVY YLSQLCGDPQ RFDDFLRAYV EKYKFTSVVA
   481  QDLLDSFLSF FPELKEQSVD CRAGLEFERW LNATGPPLAE PDLSQGSSLT RPVEALFQLW
   541  TAEPLDQAAA SASAIDISKW RTFQTALFLD RLLDGSPLPQ EVVMSLSKCY SSLLDSMNAE
   601  IRIRWLQIVV RNDYYPDLHR VRRFLESQMS RMYTIPLYED LCTGALKSFA LEVFYQTQGR
   661  LHPNLRRAIQ QILSQGLGSS TEPASEPSTE LGKAEADTDS DAQALLLGDE APSSAISLRD
   721  VNVSA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNPEPL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 77 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 77 nTPM
pancreas: 63 nTPM
skeletal muscle: 63 nTPM
spleen: 56 nTPM
esophagus: 53 nTPM
liver: 51 nTPM

Single-cell type

esophageal apical cells: 169 nCPM
megakaryocytes: 161 nCPM
foveolar cells: 122 nCPM
colonocytes: 108 nCPM
platelets: 76 nCPM
monocytes: 74 nCPM

Immune cell

eosinophil: 31 nTPM
neutrophil: 20 nTPM
gdT-cell: 15 nTPM
T-reg: 15 nTPM
memory CD8 T-cell: 13 nTPM
MAIT T-cell: 13 nTPM

Brain region

medulla oblongata: 21 nTPM
thalamus: 21 nTPM
spinal cord: 20 nTPM
white matter: 20 nTPM
midbrain: 17 nTPM
pons: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.79
gnomAD pLI: 0
gnomAD missense Z: 2.22

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

proteolysis

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNPEPL1 as an antibody target. Whether an autoantibody or antibody against RNPEPL1 could matter depends on whether native RNPEPL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNPEPL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RNPEPL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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