Seroatlas · Human Serome Atlas

RNLS

Renalase

Also known as: C10orf59, FLJ11218, renalase, RNLS_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VYX0
Gene: RNLS
Ensembl: ENSG00000184719
Chromosome: 10
Canonical length: 342 aa
Protein class: Enzymes, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

Enables several functions, including NADH binding activity; epinephrine binding activity; and monoamine oxidase activity. Involved in negative regulation of blood pressure and negative regulation of heart rate. Located in extracellular region. Implicated in essential hypertension and hypertension. Biomarker of end stage renal disease. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

342 residues, UniProt reviewed canonical sequence.

>Q5VYX0|RNLS
     1  MAQVLIVGAG MTGSLCAALL RRQTSGPLYL AVWDKAEDSG GRMTTACSPH NPQCTADLGA
    61  QYITCTPHYA KKHQRFYDEL LAYGVLRPLS SPIEGMVMKE GDCNFVAPQG ISSIIKHYLK
   121  ESGAEVYFRH RVTQINLRDD KWEVSKQTGS PEQFDLIVLT MPVPEILQLQ GDITTLISEC
   181  QRQQLEAVSY SSRYALGLFY EAGTKIDVPW AGQYITSNPC IRFVSIDNKK RNIESSEIGP
   241  SLVIHTTVPF GVTYLEHSIE DVQELVFQQL ENILPGLPQP IATKCQKWRH SQVTNAAANC
   301  PGQMTLHHKP FLACGGDGFT QSNFDGCITS ALCVLEALKN YI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNLS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

kidney: 15 nTPM
choroid plexus: 13 nTPM
adrenal gland: 13 nTPM
skeletal muscle: 11 nTPM
heart muscle: 11 nTPM
tongue: 9.1 nTPM

Single-cell type

thymic myoid cells: 1,052 nCPM
myonuclei: 352 nCPM
choroid plexus epithelial cells: 259 nCPM
ependymal cells: 254 nCPM
thyrotrophs: 211 nCPM
lactotrophs: 188 nCPM

Immune cell

intermediate monocyte: 3.6 nTPM
myeloid DC: 3.1 nTPM
NK-cell: 2.7 nTPM
plasmacytoid DC: 2.7 nTPM
memory B-cell: 2.5 nTPM
non-classical monocyte: 2.4 nTPM

Brain region

choroid plexus: 17 nTPM
midbrain: 16 nTPM
cerebellum: 15 nTPM
medulla oblongata: 13 nTPM
pons: 9.9 nTPM
cerebral cortex: 9.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.06
gnomAD pLI: 0
gnomAD missense Z: 0.02
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNLS as an antibody target. Whether an autoantibody or antibody against RNLS could matter depends on whether native RNLS is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNLS is annotated as secreted, so native RNLS circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label RNLS as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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