Seroatlas · Human Serome Atlas

RNF44

RING finger protein 44

Also known as: KIAA1100, RNF44_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7L0R7
Gene: RNF44
Ensembl: ENSG00000146083
Chromosome: 5
Canonical length: 432 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

432 residues, UniProt reviewed canonical sequence.

>Q7L0R7|RNF44
     1  MRPWALAVTR WPPSAPVGQR RFSAGPGSTP GQLWGSPGLE GPLASPPARD ERLPSQQPPS
    61  RPPHLPVEER RASAPAGGSP RMLHPATQQS PFMVDLHEQV HQGPVPLSYT VTTVTTQGFP
   121  LPTGQHIPGC SAQQLPACSV MFSGQHYPLC CLPPPLIQAC TMQQLPVPYQ AYPHLISSDH
   181  YILHPPPPAP PPQPTHMAPL GQFVSLQTQH PRMPLQRLDN DVDLRGDQPS LGSFTYSTSA
   241  PGPALSPSVP LHYLPHDPLH QELSFGVPYS HMMPRRLSTQ RYRLQQPLPP PPPPPPPPPY
   301  YPSFLPYFLS MLPMSPTAMG PTISLDLDVD DVEMENYEAL LNLAERLGDA KPRGLTKADI
   361  EQLPSYRFNP DSHQSEQTLC VVCFSDFEAR QLLRVLPCNH EFHTKCVDKW LKANRTCPIC
   421  RADASEVPRE AE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNF44 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 52 nTPM

Expression across tissuesHPA

Tissue

spleen: 52 nTPM
bone marrow: 40 nTPM
lymph node: 35 nTPM
small intestine: 33 nTPM
cerebellum: 30 nTPM
skin: 29 nTPM

Single-cell type

late spermatids: 765 nCPM
early spermatids: 125 nCPM
neutrophils: 121 nCPM
parietal cells: 64 nCPM
kupffer cells: 61 nCPM
neutrophil progenitors: 57 nCPM

Immune cell

neutrophil: 5.3 nTPM
T-reg: 3.1 nTPM
gdT-cell: 3 nTPM
eosinophil: 2.9 nTPM
naive CD8 T-cell: 2.7 nTPM
memory CD8 T-cell: 2.5 nTPM

Brain region

cerebral cortex: 45 nTPM
amygdala: 44 nTPM
thalamus: 44 nTPM
hypothalamus: 42 nTPM
hippocampal formation: 38 nTPM
basal ganglia: 37 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.5
gnomAD pLI: 0.27
gnomAD missense Z: 0.39
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein ubiquitination

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNF44 as an antibody target. Whether an autoantibody or antibody against RNF44 could matter depends on whether native RNF44 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNF44 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RNF44 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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