Seroatlas · Human Serome Atlas

RNF38

E3 ubiquitin-protein ligase RNF38

Also known as: RNF38_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H0F5
Gene
RNF38
Ensembl
ENSG00000137075
Chromosome
9
Canonical length
515 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes a protein with a coiled-coil motif and a RING-H2 motif (C3H2C2) at its carboxy-terminus. The RING motif is a zinc-binding domain found in a large set of proteins playing roles in diverse cellular processes including oncogenesis, development, signal transduction, and apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

Canonical amino-acid sequenceUniProt

515 residues, UniProt reviewed canonical sequence.

>Q9H0F5|RNF38
     1  MACKISPGAN SASLPGHPNK VICERVRLQS LFPLLPSDQN TTVQEDAHFK AFFQSEDSPS
    61  PKRQRLSHSV FDYTSASPAP SPPMRPWEMT SNRQPPSVRP SQHHFSGERC NTPARNRRSP
   121  PVRRQRGRRD RLSRHNSISQ DENYHHLPYA QQQAIEEPRA FHPPNVSPRL LHPAAHPPQQ
   181  NAVMVDIHDQ LHQGTVPVSY TVTTVAPHGI PLCTGQHIPA CSTQQVPGCS VVFSGQHLPV
   241  CSVPPPMLQA CSVQHLPVPY AAFPPLISSD PFLIHPPHLS PHHPPHLPPP GQFVPFQTQQ
   301  SRSPLQRIEN EVELLGEHLP VGGFTYPPSA HPPTLPPSAP LQFLTHDPLH QEVSFGVPYP
   361  PFMPRRLTGR SRYRSQQPIP PPPYHPSLLP YVLSMLPVPP AVGPTFSFEL DVEDGEVENY
   421  EALLNLAERL GEAKPRGLTK ADIEQLPSYR FNPNNHQSEQ TLCVVCMCDF ESRQLLRVLP
   481  CNHEFHAKCV DKWLKANRTC PICRADASEV HRDSE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNF38 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.67
Highest tissue expression
65 nTPM

Expression across tissuesHPA

Tissue

  • testis: 65 nTPM
  • bone marrow: 36 nTPM
  • ovary: 30 nTPM
  • blood vessel: 25 nTPM
  • retina: 22 nTPM
  • endometrium: 22 nTPM

Single-cell type

  • late spermatids: 2,377 nCPM
  • early spermatids: 664 nCPM
  • sertoli cells: 585 nCPM
  • bergmann glia: 432 nCPM
  • neutrophil progenitors: 281 nCPM
  • pancreatic acinar cells: 272 nCPM

Immune cell

  • basophil: 11 nTPM
  • T-reg: 6 nTPM
  • NK-cell: 5.9 nTPM
  • neutrophil: 5.3 nTPM
  • eosinophil: 5.1 nTPM
  • memory CD8 T-cell: 4.7 nTPM

Brain region

  • cerebral cortex: 46 nTPM
  • cerebellum: 45 nTPM
  • midbrain: 37 nTPM
  • hypothalamus: 36 nTPM
  • basal ganglia: 35 nTPM
  • thalamus: 34 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RNF38.

Disease | ImmuneIEDB

Conditions an epitope on RNF38 was assayed in.

  • Merkel cell carcinoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.14
gnomAD pLI
1
gnomAD missense Z
1.56
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNF38 as an antibody target. Whether an autoantibody or antibody against RNF38 could matter depends on whether native RNF38 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNF38 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RNF38 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RNF38. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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