Seroatlas · Human Serome Atlas

RNF32-DT

Putative transmembrane protein RNF32-DT

Also known as: R32DT_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NI28
Gene: RNF32-DT
Canonical length: 216 aa

OverviewNCBI Gene

No narrative summary is available for RNF32-DT in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

216 residues, UniProt reviewed canonical sequence.

>Q8NI28|RNF32-DT
     1  MLASPARPTL RMLANHALST PHCACSPAPA PRTASASRRR CVPVEARAAG VFGDRLAGVF
    61  GSRGLKHGGV QAPRPRVVRA EPRAGFAVVR SPRRLCGRSH APQPPAHLGL GPGCFPAVAV
   121  VVPVPGSRAH RPFAALLVEG SFLGDPPIPP RRSGVLARGS AGADCLASSV TPGPSLWIPL
   181  LLVAGCVSCF VGLAVCVWMQ ARVSPAWPAG LFLLPR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNF32-DT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.63

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNF32-DT as an antibody target. Whether an autoantibody or antibody against RNF32-DT could matter depends on whether native RNF32-DT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNF32-DT is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RNF32-DT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...