Seroatlas · Human Serome Atlas

RNF228

RING finger protein 228

Also known as: RN228_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0A7I2V3R4
Gene: RNF228
Canonical length: 345 aa

OverviewNCBI Gene

No narrative summary is available for RNF228 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

345 residues, UniProt reviewed canonical sequence.

>A0A7I2V3R4|RNF228
     1  MAAPASDSGG SQQSPSSSPG SREGAGVAAK GAPDCGDAGA RDAAETVSGL PPLEDYECKI
    61  CYNYFDADRR APKLLACLHT FCQECLSQLQ LRAAAAAAAA AAPERPPRPP PWLCPPGAIA
   121  CPVCRHRTPL PDSRVHGLPN NTKLAEAFPL ALRAAHDPLP QDRLPPLPAR LPAPAAAPPP
   181  TPAPPPPPSP APPQPPPPPP AEDAAPGPRA RPGLRAPGAY DSCQNCKRAA LTAGCVCVVF
   241  SFLSMVVLLF TGLIFVNHYG GGGTPGGGAP PGEAPATGSP SPSPVGPICL SVASILALFS
   301  VVVTWVICWL KYRPEGAAAG STGGSGGGGG PRARAAAGGA RRSDT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNF228 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.56

OntologyGO

Biological processes

protein ubiquitination

Molecular functions

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNF228 as an antibody target. Whether an autoantibody or antibody against RNF228 could matter depends on whether native RNF228 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNF228 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RNF228 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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