Seroatlas · Human Serome Atlas

RNF227

RING finger protein 227

Also known as: LINC02581, RN227_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6NIN4
Gene
RNF227
Ensembl
ENSG00000179859
Chromosome
17
Canonical length
190 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

190 residues, UniProt reviewed canonical sequence.

>A6NIN4|RNF227
     1  MQLLVRVPSL PERGELDCNI CYRPFNLGCR APRRLPGTAR ARCGHTICTA CLRELAARGD
    61  GGGAAARVVR LRRVVTCPFC RAPSQLPRGG LTEMALDSDL WSRLEEKARA KCERDEAGNP
   121  AKESSDADGE AEEEGESEKG AGPRSAGWRA LRRLWDRVLG PARRWRRPLP SNVLYCAEIK
   181  DIGHLTRCTL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNF227 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
61 nTPM

Expression across tissuesHPA

Tissue

  • skin: 61 nTPM
  • retina: 11 nTPM
  • cerebellum: 8.9 nTPM
  • endometrium: 5.7 nTPM
  • adipose tissue: 5.5 nTPM
  • basal ganglia: 4.8 nTPM

Single-cell type

  • basal keratinocytes: 32 nCPM
  • suprabasal keratinocytes: 19 nCPM
  • medullary thymic epithelial cells: 12 nCPM
  • respiratory ciliated cells: 12 nCPM
  • tuft cells: 12 nCPM
  • conjunctival goblet cells: 11 nCPM

Immune cell

  • basophil: 18 nTPM
  • naive CD4 T-cell: 3.5 nTPM
  • NK-cell: 2.7 nTPM
  • naive CD8 T-cell: 2.4 nTPM
  • MAIT T-cell: 2.2 nTPM
  • memory CD8 T-cell: 2.2 nTPM

Brain region

  • cerebellum: 11 nTPM
  • cerebral cortex: 10 nTPM
  • hypothalamus: 8.3 nTPM
  • basal ganglia: 8.1 nTPM
  • amygdala: 7.7 nTPM
  • medulla oblongata: 7.5 nTPM

OntologyGO

Biological processes

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNF227 as an antibody target. Whether an autoantibody or antibody against RNF227 could matter depends on whether native RNF227 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNF227 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RNF227 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RNF227. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...