Seroatlas · Human Serome Atlas

RNF225

RING finger protein 225

Also known as: RN225_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: M0QZC1
Gene: RNF225
Ensembl: ENSG00000269855
Chromosome: 19
Canonical length: 329 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

329 residues, UniProt reviewed canonical sequence.

>M0QZC1|RNF225
     1  MPCPRPFWLR HSRAPQGSGP SSPGSLSAPR SPSRGEDQEE EEEEEGDGSP GSGPILPPAS
    61  PVECLICVSS FDGVFKLPKR LDCGHVFCLE CLARLSLATA GGGNAVACPV CRAPTRLAPR
   121  RGLPALPTQS GLLPRDARAP PSRQGSVRFD RRRGLLYLRP PPPPPGPRKA RAPPPPPPLR
   181  LGRPLSRRLS LASPAWVFNA AVALAVLVAA GLVVSGVYIF FLIPHATSSG PPRPQLVALA
   241  PAPGFSWFPP RPPPGSPWAP AWTPRPTGPD LDTALPGTAE DALEPEAGPE DPAEAERTLD
   301  RRSDGTWGTE AGPGWAPWPR GARRLWGSQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNF225 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.57
Highest tissue expression: 5.6 nTPM

Expression across tissuesHPA

Tissue

esophagus: 5.6 nTPM
skin: 4.2 nTPM
cervix: 2.6 nTPM
vagina: 2.4 nTPM
salivary gland: 1 nTPM
prostate: 0.2 nTPM

Single-cell type

esophageal apical cells: 0.2 nCPM
suprabasal keratinocytes: 0.2 nCPM
transitional alveolar cells: 0.2 nCPM
corticotrophs: 0.1 nCPM
enteric transient amplifying cells: 0.1 nCPM
enterocytes: 0.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 1.5 nTPM
hypothalamus: 0.5 nTPM
cerebral cortex: 0.4 nTPM
hippocampal formation: 0.3 nTPM
medulla oblongata: 0.3 nTPM
pons: 0.3 nTPM

OntologyGO

Biological processes

protein ubiquitination

Molecular functions

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNF225 as an antibody target. Whether an autoantibody or antibody against RNF225 could matter depends on whether native RNF225 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNF225 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RNF225 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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