Seroatlas · Human Serome Atlas

RNF222

RING finger protein 222

Also known as: RN222_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NCQ9
Gene: RNF222
Ensembl: ENSG00000189051
Chromosome: 17
Canonical length: 220 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable zinc ion binding activity. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

220 residues, UniProt reviewed canonical sequence.

>A6NCQ9|RNF222
     1  MSEGESKDSS GSECPVCYEK FRDLEGASRT LSCGHVFCHD CLVKYLLSTR VDGQVQRTLV
    61  CPICRYVTFL SKKSSRWPSM LDKSSQTLAV PVGLPSVPPL DSLGHTNPLA ASSPAWRPPP
   121  GQARPPGSPG QSAQLPLDLL PSLPRESQIF VISRHGMPLG EQDSVLPRRS LAELSEASLA
   181  PRSARAFCCR SRALLLITLI AVVAVVAAIL PWVLLVRKQA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNF222 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

esophagus: 17 nTPM
skin: 6.7 nTPM
vagina: 5.7 nTPM
cervix: 4.6 nTPM
tonsil: 2.1 nTPM
salivary gland: 1.7 nTPM

Single-cell type

esophageal apical cells: 204 nCPM
suprabasal keratinocytes: 7.6 nCPM
neutrophils: 3.8 nCPM
esophageal suprabasal cells: 2.9 nCPM
thymic myoid cells: 2.7 nCPM
ocular epithelial cells: 1.8 nCPM

Immune cell

basophil: 0.3 nTPM
neutrophil: 0.2 nTPM
eosinophil: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebellum: 2.5 nTPM
white matter: 2.2 nTPM
medulla oblongata: 2.1 nTPM
cerebral cortex: 2 nTPM
choroid plexus: 1.8 nTPM
hippocampal formation: 1.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.86
gnomAD pLI: 0
gnomAD missense Z: 0.58
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

zinc ion binding

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNF222 as an antibody target. Whether an autoantibody or antibody against RNF222 could matter depends on whether native RNF222 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNF222 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RNF222 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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