Seroatlas · Human Serome Atlas

RNF215

RING finger protein 215

Also known as: RN215_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y6U7
Gene: RNF215
Ensembl: ENSG00000099999
Chromosome: 22
Canonical length: 377 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoli,Microtubules

OverviewNCBI Gene

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to be located in membrane. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

377 residues, UniProt reviewed canonical sequence.

>Q9Y6U7|RNF215
     1  MGPAARPALR SPPPPPPPPP SPLLLLLPLL PLWLGLAGPG AAADGSEPAA GAGRGGARAV
    61  RVDVRLPRQD ALVLEGVRIG SEADPAPLLG GRLLLMDIVD AEQEAPVEGW IAVAYVGKEQ
   121  AAQFHQENKG SGPQAYPKAL VQQMRRALFL GASALLLLIL NHNVVRELDI SQLLLRPVIV
   181  LHYSSNVTKL LDALLQRTQA TAEITSGESL SANIEWKLTL WTTCGLSKDG YGGWQDLVCL
   241  GGSRAQEQKP LQQLWNAILL VAMLLCTGLV VQAQRQASRQ SQRELGGQVD LFKRRVVRRL
   301  ASLKTRRCRL SRAAQGLPDP GAETCAVCLD YFCNKQWLRV LPCKHEFHRD CVDPWLMLQQ
   361  TCPLCKFNVL GNRYSDD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNF215 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 25 nTPM
cerebral cortex: 19 nTPM
cervix: 17 nTPM
hypothalamus: 16 nTPM
basal ganglia: 15 nTPM
amygdala: 15 nTPM

Single-cell type

epicardial cells: 66 nCPM
proximal tubule cells: 52 nCPM
müller glia: 48 nCPM
myonuclei: 45 nCPM
retinal ganglion cells: 35 nCPM
early primary spermatocytes: 34 nCPM

Immune cell

NK-cell: 2.5 nTPM
naive B-cell: 1.9 nTPM
naive CD4 T-cell: 1.8 nTPM
naive CD8 T-cell: 1.7 nTPM
eosinophil: 1.5 nTPM
plasmacytoid DC: 1.4 nTPM

Brain region

hypothalamus: 30 nTPM
medulla oblongata: 30 nTPM
cerebral cortex: 29 nTPM
amygdala: 28 nTPM
midbrain: 28 nTPM
basal ganglia: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.3
gnomAD pLI: 0
gnomAD missense Z: 0.5
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

ubiquitin-dependent protein catabolic process

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNF215 as an antibody target. Whether an autoantibody or antibody against RNF215 could matter depends on whether native RNF215 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNF215 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RNF215 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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