Seroatlas · Human Serome Atlas

RNF212B

E3 ubiquitin-protein ligase RNF212B

Also known as: C14orf164, R212B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A8MTL3
Gene: RNF212B
Ensembl: ENSG00000215277
Chromosome: 14
Canonical length: 300 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Nucleoli fibrillar center,Golgi apparatus
Quaternary structure: Homodimer

OverviewNCBI Gene

Predicted to enable SUMO transferase activity and ubiquitin protein ligase activity. Predicted to be involved in chiasma assembly and protein ubiquitination. Predicted to be located in chromosome. Predicted to be active in synaptonemal complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

300 residues, UniProt reviewed canonical sequence.

>A8MTL3|RNF212B
     1  MDWFHCNQCF RKDGAHFFVT SCGHIFCKKC VTLEKCAVCG TACKHLALSD NLKPQEKMFF
    61  KSPVETALQY FSHISQVWSF QKKQTDLLIA FYKHRITKLE TAMQEAQQAL VSQDKELSVL
   121  RKENGELKKF LAILKESPSR YQGSRSITPR PVGITSPSQS VTPRPSFQHS SQVVSRSSSA
   181  ESIPYREAGF GSLGQGGRGL QGRRTPRDSY NETPSPASTH SLSYRTSSAS SGQGIFSFRP
   241  SPNGHSGHTR VLTPNNFAQR ESTTTLESLP SFQLPVLQTL YQQRRHMGLP SGREAWTTSR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNF212B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

kidney: 24 nTPM
testis: 4.5 nTPM
retina: 0.4 nTPM
thyroid gland: 0.4 nTPM
fallopian tube: 0.2 nTPM
lymph node: 0.2 nTPM

Single-cell type

proximal tubule cells: 490 nCPM
early primary spermatocytes: 155 nCPM
late primary spermatocytes: 49 nCPM
early spermatids: 38 nCPM
sertoli cells: 37 nCPM
retinal bipolar cells: 32 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 2.8 nTPM
cerebral cortex: 2.5 nTPM
thalamus: 1.7 nTPM
hippocampal formation: 1.6 nTPM
amygdala: 1.5 nTPM
hypothalamus: 1.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RNF212B.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 2 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Female infertility

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.14
gnomAD pLI: 0
DepMap mean gene effect: -0.31
DepMap dependency class: selective

OntologyGO

Biological processes

Molecular functions

Cellular components

synaptonemal complex

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNF212B as an antibody target. Whether an autoantibody or antibody against RNF212B could matter depends on whether native RNF212B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNF212B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RNF212B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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