RNF208
RING finger protein 208
Also known as: DKFZP761H1710, RN208_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9H0X6
- Gene
- RNF208
- Ensembl
- ENSG00000212864
- Chromosome
- 9
- Canonical length
- 261 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
Enables ubiquitin-protein transferase activity. Involved in protein autoubiquitination. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
261 residues, UniProt reviewed canonical sequence.
>Q9H0X6|RNF208
1 MPSDPGPEAG SGWPGLLMSC LKGPHVILKM EAMKIVHPEK FPELPAAPCF PPAPRPTPTL
61 APKRAWPSDT EIIVNQACGG DMPALEGAPH TPPLPRRPRK GSSELGFPRV APEDEVIVNQ
121 YVIRPGPSAS AASSAAAGEP LECPTCGHSY NVTQRRPRVL SCLHSVCEQC LQILYESCPK
181 YKFISCPTCR RETVLFTDYG LAALAVNTSI LSRLPPEALT APSGGQWGAE PEGSCYQTFR
241 QYCGAACTCH VRNPLSACSI MLocalizationUniProt · AlphaFold · HPA
Whether an antibody against RNF208 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.54
- Highest tissue expression
- 134 nTPM
Expression across tissuesHPA
Tissue
- cerebral cortex: 134 nTPM
- hippocampal formation: 106 nTPM
- amygdala: 96 nTPM
- basal ganglia: 68 nTPM
- hypothalamus: 59 nTPM
- cerebellum: 52 nTPM
Single-cell type
- esophageal apical cells: 86 nCPM
- platelets: 68 nCPM
- parietal cells: 23 nCPM
- megakaryocytes: 19 nCPM
- brain excitatory neurons: 17 nCPM
- brain inhibitory neurons: 17 nCPM
Immune cell
- MAIT T-cell: 0.1 nTPM
- neutrophil: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
Brain region
- cerebral cortex: 188 nTPM
- hippocampal formation: 117 nTPM
- white matter: 111 nTPM
- amygdala: 103 nTPM
- basal ganglia: 93 nTPM
- pons: 92 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.51
- gnomAD pLI
- 0.83
- gnomAD missense Z
- 1.24
- DepMap mean gene effect
- 0.13
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Zinc finger, RING-type
- Zinc finger, RING/FYVE/PHD-type
- Zinc finger, RING-type, conserved site
- RING finger E3 ubiquitin-protein ligases
- RING finger protein 208, HC type RING finger
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads RNF208 as an antibody target. Whether an autoantibody or antibody against RNF208 could matter depends on whether native RNF208 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
RNF208 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label RNF208 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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