Seroatlas · Human Serome Atlas

RNF151

RING finger protein 151

Also known as: RN151_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q2KHN1
Gene: RNF151
Ensembl: ENSG00000179580
Chromosome: 16
Canonical length: 245 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles,Vesicles,Cytosol

OverviewNCBI Gene

Predicted to enable enzyme binding activity; identical protein binding activity; and zinc ion binding activity. Predicted to be involved in cell differentiation and spermatogenesis. Predicted to be located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

245 residues, UniProt reviewed canonical sequence.

>Q2KHN1|RNF151
     1  MGGGYDLNLF ASPPDSNFVC SVCHGVLKRP ARLPCSHIFC KKCILRWLAR QKTCPCCRKE
    61  VKRKKVVHMN KLRKTIGRLE VKCKNADAGC IVTCPLAHRK GHQDSCPFEL TACPNEGCTS
   121  QVPRGTLAEH RQHCQQGSQQ RCPLGCGATL DPAERARHNC YRELHNAWSV RQERRRPLLL
   181  SLLRRVRWLD QATSVVRREL AELSNFLEED TALLEGAPQE EAEAAPEGNV GAEVVGEPRA
   241  NIPCK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNF151 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 186 nTPM

Expression across tissuesHPA

Tissue

testis: 186 nTPM
breast: 0.1 nTPM
cerebellum: 0.1 nTPM
colon: 0.1 nTPM
kidney: 0.1 nTPM
liver: 0.1 nTPM

Single-cell type

early spermatids: 2,667 nCPM
late spermatids: 1,977 nCPM
late primary spermatocytes: 333 nCPM
sertoli cells: 12 nCPM
leydig cells: 4.6 nCPM
peritubular myoid cells: 2.4 nCPM

Immune cell

T-reg: 0.3 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

white matter: 1.3 nTPM
cerebellum: 1.2 nTPM
basal ganglia: 1 nTPM
medulla oblongata: 0.9 nTPM
pons: 0.9 nTPM
cerebral cortex: 0.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.65
gnomAD pLI: 0
gnomAD missense Z: 0.31
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RNF151 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

DTNBP1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNF151 as an antibody target. Whether an autoantibody or antibody against RNF151 could matter depends on whether native RNF151 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNF151 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RNF151 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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