Seroatlas · Human Serome Atlas

RNF150

RING finger protein 150

Also known as: KIAA1214, RN150_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9ULK6
Gene: RNF150
Ensembl: ENSG00000170153
Chromosome: 4
Canonical length: 438 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to be located in membrane. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

438 residues, UniProt reviewed canonical sequence.

>Q9ULK6|RNF150
     1  MAMSLIQACC SLALSTWLLS FCFVHLLCLD FTVAEKEEWY TAFVNITYAE PAPDPGAGAA
    61  GGGGAELHTE KTECGRYGEH SPKQDARGEV VMASSAHDRL ACDPNTKFAA PTRGKNWIAL
   121  IPKGNCTYRD KIRNAFLQNA SAVVIFNVGS NTNETITMPH AGVEDIVAIM IPEPKGKEIV
   181  SLLERNITVT MYITIGTRNL QKYVSRTSVV FVSISFIVLM IISLAWLVFY YIQRFRYANA
   241  RDRNQRRLGD AAKKAISKLQ IRTIKKGDKE TESDFDNCAV CIEGYKPNDV VRILPCRHLF
   301  HKSCVDPWLL DHRTCPMCKM NILKALGIPP NADCMDDLPT DFEGSLGGPP TNQITGASDT
   361  TVNESSVTLD PAVRTVGALQ VVQDTDPIPQ EGDVIFTTNS EQEPAVSSDS DISLIMAMEV
   421  GLSDVELSTD QDCEEVKS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNF150 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 30 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 30 nTPM
retina: 29 nTPM
skeletal muscle: 18 nTPM
colon: 14 nTPM
heart muscle: 14 nTPM
adrenal gland: 12 nTPM

Single-cell type

lactotrophs: 1,282 nCPM
thyrotrophs: 724 nCPM
retinal pigment epithelial cells: 674 nCPM
cardiomyocytes: 672 nCPM
salivary acinar cells: 641 nCPM
adipocytes: 598 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

basal ganglia: 41 nTPM
hypothalamus: 32 nTPM
cerebral cortex: 31 nTPM
cerebellum: 30 nTPM
pons: 28 nTPM
hippocampal formation: 25 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RNF150.

Disease | ImmuneIEDB

Conditions an epitope on RNF150 was assayed in.

narcolepsy B cell
multiple sclerosis B cell
peripheral nervous system disease B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.82
gnomAD pLI: 0
gnomAD missense Z: 0.97
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

ubiquitin-dependent protein catabolic process

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNF150 as an antibody target. Whether an autoantibody or antibody against RNF150 could matter depends on whether native RNF150 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNF150 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RNF150 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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