Seroatlas · Human Serome Atlas

RNF141

RING finger protein 141

Also known as: RN141_HUMAN, ZFP26, ZNF230

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WVD5
Gene: RNF141
Ensembl: ENSG00000110315
Chromosome: 11
Canonical length: 230 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Microtubules

OverviewNCBI Gene

The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-DNA and protein-protein interactions. Abundant expression of this gene was found in the testicular tissue of fertile men, but was not detected in azoospermic patients. Studies of the mouse counterpart suggest that this gene may function as a testis specific transcription factor during spermatogenesis. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

230 residues, UniProt reviewed canonical sequence.

>Q8WVD5|RNF141
     1  MGQQISDQTQ LVINKLPEKV AKHVTLVRES GSLTYEEFLG RVAELNDVTA KVASGQEKHL
    61  LFEVQPGSDS SAFWKVVVRV VCTKINKSSG IVEASRIMNL YQFIQLYKDI TSQAAGVLAQ
   121  SSTSEEPDEN SSSVTSCQAS LWMGRVKQLT DEEECCICMD GRADLILPCA HSFCQKCIDK
   181  WSDRHRNCPI CRLQMTGANE SWVVSDAPTE DDMANYILNM ADEAGQPHRP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNF141 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 89 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 89 nTPM
testis: 76 nTPM
midbrain: 71 nTPM
esophagus: 53 nTPM
hippocampal formation: 44 nTPM
cerebral cortex: 43 nTPM

Single-cell type

early spermatids: 1,168 nCPM
late spermatids: 839 nCPM
esophageal apical cells: 696 nCPM
late primary spermatocytes: 327 nCPM
neutrophils: 156 nCPM
esophageal suprabasal cells: 148 nCPM

Immune cell

neutrophil: 153 nTPM
intermediate monocyte: 107 nTPM
non-classical monocyte: 105 nTPM
eosinophil: 93 nTPM
naive B-cell: 70 nTPM
memory B-cell: 68 nTPM

Brain region

white matter: 144 nTPM
medulla oblongata: 115 nTPM
basal ganglia: 109 nTPM
cerebellum: 101 nTPM
spinal cord: 93 nTPM
midbrain: 92 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.15
gnomAD pLI: 0
gnomAD missense Z: 1.04
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNF141 as an antibody target. Whether an autoantibody or antibody against RNF141 could matter depends on whether native RNF141 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNF141 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RNF141 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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