Seroatlas · Human Serome Atlas

RNF133

E3 ubiquitin-protein ligase RNF133

Also known as: RN133_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WVZ7
Gene: RNF133
Ensembl: ENSG00000188050
Chromosome: 7
Canonical length: 376 aa
Protein class: Enzymes, Metabolic proteins, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene has no intron. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

376 residues, UniProt reviewed canonical sequence.

>Q8WVZ7|RNF133
     1  MHLLKVGTWR NNTASSWLMK FSVLWLVSQN CCRASVVWMA YMNISFHVGN HVLSELGETG
    61  VFGRSSTLKR VAGVIVPPEG KIQNACNPNT IFSRSKYSET WLALIERGGC TFTQKIKVAT
   121  EKGASGVIIY NVPGTGNQVF PMFHQAFEDV VVVMIGNLKG TEIFHLIKKG VLITAVVEVG
   181  RKHIIWMNHY LVSFVIVTTA TLAYFIFYHI HRLCLARIQN RRWQRLTTDL QNTFGQLQLR
   241  VVKEGDEEIN PNGDSCVICF ERYKPNDIVR ILTCKHFFHK NCIDPWILPH GTCPICKCDI
   301  LKVLGIQVVV ENGTEPLQVL MSNELPETLS PSEEETNNEV SPAGTSDKVI HVEENPTSQN
   361  NDIQPHSVVE DVHPSP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNF133 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 41 nTPM

Expression across tissuesHPA

Tissue

testis: 41 nTPM
endometrium: 0.6 nTPM
cerebellum: 0.4 nTPM
lung: 0.3 nTPM
salivary gland: 0.3 nTPM
adipose tissue: 0.2 nTPM

Single-cell type

late spermatids: 99 nCPM
early spermatids: 40 nCPM
late primary spermatocytes: 6.7 nCPM
epididymal basal cells: 0.3 nCPM
early primary spermatocytes: 0.2 nCPM
differentiating spermatogonia: 0.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 16 nTPM
cerebral cortex: 4.3 nTPM
white matter: 2.8 nTPM
hypothalamus: 2.2 nTPM
midbrain: 1.8 nTPM
pons: 1.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.87
gnomAD pLI: 0.04
gnomAD missense Z: -0.38
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNF133 as an antibody target. Whether an autoantibody or antibody against RNF133 could matter depends on whether native RNF133 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNF133 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RNF133 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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