Seroatlas · Human Serome Atlas

RNF130

E3 ubiquitin-protein ligase RNF130

Also known as: G1RZFP, GOLI_HUMAN, GOLIATH, GP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86XS8
Gene: RNF130
Ensembl: ENSG00000113269
Chromosome: 5
Canonical length: 419 aa
Protein class: Enzymes, Metabolic proteins, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene contains a RING finger motif and is similar to g1, a Drosophila zinc-finger protein that is expressed in mesoderm and involved in embryonic development. The expression of the mouse counterpart was found to be upregulated in myeloblastic cells following IL3 deprivation, suggesting that this gene may regulate growth factor withdrawal-induced apoptosis of myeloid precursor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

419 residues, UniProt reviewed canonical sequence.

>Q86XS8|RNF130
     1  MSCAGRAGPA RLAALALLTC SLWPARADNA SQEYYTALIN VTVQEPGRGA PLTFRIDRGR
    61  YGLDSPKAEV RGQVLAPLPL HGVADHLGCD PQTRFFVPPN IKQWIALLQR GNCTFKEKIS
   121  RAAFHNAVAV VIYNNKSKEE PVTMTHPGTG DIIAVMITEL RGKDILSYLE KNISVQMTIA
   181  VGTRMPPKNF SRGSLVFVSI SFIVLMIISS AWLIFYFIQK IRYTNARDRN QRRLGDAAKK
   241  AISKLTTRTV KKGDKETDPD FDHCAVCIES YKQNDVVRIL PCKHVFHKSC VDPWLSEHCT
   301  CPMCKLNILK ALGIVPNLPC TDNVAFDMER LTRTQAVNRR SALGDLAGDN SLGLEPLRTS
   361  GISPLPQDGE LTPRTGEINI AVTKEWFIIA SFGLLSALTL CYMIIRATAS LNANEVEWF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNF130 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 168 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 168 nTPM
liver: 156 nTPM
midbrain: 99 nTPM
bone marrow: 89 nTPM
adipose tissue: 88 nTPM
choroid plexus: 87 nTPM

Single-cell type

megakaryocyte-erythroid progenitors: 1,593 nCPM
neutrophils: 1,383 nCPM
megakaryocyte progenitors: 1,109 nCPM
mast cells: 864 nCPM
oligodendrocytes: 719 nCPM
kupffer cells: 612 nCPM

Immune cell

neutrophil: 894 nTPM
classical monocyte: 514 nTPM
myeloid DC: 408 nTPM
intermediate monocyte: 355 nTPM
eosinophil: 332 nTPM
non-classical monocyte: 330 nTPM

Brain region

white matter: 186 nTPM
medulla oblongata: 145 nTPM
cerebellum: 119 nTPM
basal ganglia: 118 nTPM
pons: 114 nTPM
spinal cord: 110 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.8
gnomAD pLI: 0
gnomAD missense Z: 1.77
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNF130 as an antibody target. Whether an autoantibody or antibody against RNF130 could matter depends on whether native RNF130 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNF130 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RNF130 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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