Seroatlas · Human Serome Atlas

RNF122

RING finger protein 122

Also known as: FLJ12526, RN122_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H9V4
Gene: RNF122
Ensembl: ENSG00000133874
Chromosome: 8
Canonical length: 155 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

The encoded protein contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. The encoded protein is localized to the endoplasmic reticulum and golgi apparatus, and may be associated with cell viability. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

155 residues, UniProt reviewed canonical sequence.

>Q9H9V4|RNF122
     1  MHPFQWCNGC FCGLGLVSTN KSCSMPPISF QDLPLNIYMV IFGTGIFVFM LSLIFCCYFI
    61  SKLRNQAQSE RYGYKEVVLK GDAKKLQLYG QTCAVCLEDF KGKDELGVLP CQHAFHRKCL
   121  VKWLEVRCVC PMCNKPIASP SEATQNIGIL LDELV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNF122 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 45 nTPM

Expression across tissuesHPA

Tissue

ovary: 45 nTPM
adipose tissue: 34 nTPM
fallopian tube: 31 nTPM
lung: 27 nTPM
heart muscle: 26 nTPM
skeletal muscle: 25 nTPM

Single-cell type

myonuclei: 142 nCPM
ovarian stromal cells: 114 nCPM
smooth muscle cells: 110 nCPM
vascular endothelial cells: 83 nCPM
innate lymphoid cells: 68 nCPM
pdcs: 65 nCPM

Immune cell

plasmacytoid DC: 16 nTPM
non-classical monocyte: 12 nTPM
eosinophil: 8.9 nTPM
neutrophil: 7.6 nTPM
basophil: 5.9 nTPM
intermediate monocyte: 5 nTPM

Brain region

cerebellum: 27 nTPM
medulla oblongata: 8.2 nTPM
thalamus: 7.8 nTPM
midbrain: 6.6 nTPM
pons: 6.1 nTPM
cerebral cortex: 6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.78
gnomAD pLI: 0.14
gnomAD missense Z: 0.58
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNF122 as an antibody target. Whether an autoantibody or antibody against RNF122 could matter depends on whether native RNF122 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNF122 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RNF122 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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