RNF121
E3 ubiquitin ligase RNF121
Also known as: FLJ11099, RN121_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9H920
- Gene
- RNF121
- Ensembl
- ENSG00000137522
- Chromosome
- 11
- Canonical length
- 327 aa
- Protein class
- Enzymes, Predicted membrane proteins
- Subcellular location
- Nucleoplasm,Golgi apparatus,Vesicles
OverviewNCBI Gene
The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. Several alternatively spliced transcript variants have been noted for this gene, however, not all are likely to encode viable protein products. [provided by RefSeq, Sep 2008]
Canonical amino-acid sequenceUniProt
327 residues, UniProt reviewed canonical sequence.
>Q9H920|RNF121
1 MAAVVEVEVG GGAAGERELD EVDMSDLSPE EQWRVEHARM HAKHRGHEAM HAEMVLILIA
61 TLVVAQLLLV QWKQRHPRSY NMVTLFQMWV VPLYFTVKLH WWRFLVIWIL FSAVTAFVTF
121 RATRKPLVQT TPRLVYKWFL LIYKISYATG IVGYMAVMFT LFGLNLLFKI KPEDAMDFGI
181 SLLFYGLYYG VLERDFAEMC ADYMASTIGF YSESGMPTKH LSDSVCAVCG QQIFVDVSEE
241 GIIENTYRLS CNHVFHEFCI RGWCIVGKKQ TCPYCKEKVD LKRMFSNPWE RPHVMYGQLL
301 DWLRYLVAWQ PVIIGVVQGI NYILGLELocalizationUniProt · AlphaFold · HPA
Whether an antibody against RNF121 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 5
- Mean surface accessibility (rSASA)
- 0.33
- Highest tissue expression
- 23 nTPM
Expression across tissuesHPA
Tissue
- parathyroid gland: 23 nTPM
- epididymis: 19 nTPM
- skeletal muscle: 16 nTPM
- kidney: 15 nTPM
- duodenum: 15 nTPM
- retina: 15 nTPM
Single-cell type
- renal collecting duct intercalated cells: 90 nCPM
- proximal tubule cells: 84 nCPM
- myonuclei: 73 nCPM
- sertoli cells: 71 nCPM
- enterocytes: 69 nCPM
- salivary acinar cells: 69 nCPM
Immune cell
- basophil: 4.4 nTPM
- plasmacytoid DC: 3.7 nTPM
- MAIT T-cell: 3.5 nTPM
- memory B-cell: 3.2 nTPM
- NK-cell: 3.2 nTPM
- gdT-cell: 3 nTPM
Brain region
- choroid plexus: 13 nTPM
- cerebral cortex: 11 nTPM
- midbrain: 11 nTPM
- thalamus: 11 nTPM
- hypothalamus: 11 nTPM
- spinal cord: 11 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.49
- gnomAD pLI
- 0.32
- gnomAD missense Z
- 1.39
- DepMap mean gene effect
- -0.03
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads RNF121 as an antibody target. Whether an autoantibody or antibody against RNF121 could matter depends on whether native RNF121 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
RNF121 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label RNF121 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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