Seroatlas · Human Serome Atlas

RNF113B

RING finger protein 113B

Also known as: R113B_HUMAN, RNF161, ZNF183L1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IZP6
Gene: RNF113B
Ensembl: ENSG00000139797
Chromosome: 13
Canonical length: 322 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable zinc ion binding activity. Predicted to be involved in snoRNA splicing. Predicted to be part of U2-type spliceosomal complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

322 residues, UniProt reviewed canonical sequence.

>Q8IZP6|RNF113B
     1  MAAPPSPGRT ADQADQVCTF LFKKPGRKGA AGLRKRPACD PEHGESSSSG DEGDTVAQPP
    61  RVAPRPRGLH SWQKAAHGDR RGEEAAPESL DVVYRSTRSA KPVGPEDMGA TADFEQDTEK
   121  EHHTPTILKC SQRVQEALRG REHDHIYRGI HSYLRYLKPK DTSMGNSSSG MARKGPIRAP
   181  GHLRATVRWD YQPDICKDYK ETGFCGFGDS CKFLHDRSDY KLGWEIEREL EEGRYCICED
   241  ENHEVGSEEE EIPFRCFICR QAFQNPVVTK CRHYFCESCA LEHFRATPRC YICDQPTGGI
   301  FNPAKELMAK LQKLQAAEGK KR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNF113B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 45 nTPM

Expression across tissuesHPA

Tissue

testis: 45 nTPM
adrenal gland: 0.2 nTPM
prostate: 0.2 nTPM
bone marrow: 0.1 nTPM
kidney: 0.1 nTPM
liver: 0.1 nTPM

Single-cell type

late primary spermatocytes: 203 nCPM
early spermatids: 26 nCPM
early primary spermatocytes: 22 nCPM
late spermatids: 21 nCPM
epicardial cells: 4.5 nCPM
differentiating spermatogonia: 3.4 nCPM

Immune cell

neutrophil: 0.4 nTPM
basophil: 0.3 nTPM
eosinophil: 0.2 nTPM
non-classical monocyte: 0.1 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM

Brain region

basal ganglia: 4.5 nTPM
hypothalamus: 4.2 nTPM
amygdala: 4.1 nTPM
cerebral cortex: 4.1 nTPM
midbrain: 4 nTPM
medulla oblongata: 3.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.5
gnomAD pLI: 0.79
gnomAD missense Z: 0.76
DepMap mean gene effect: 0.09
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNF113B as an antibody target. Whether an autoantibody or antibody against RNF113B could matter depends on whether native RNF113B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNF113B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RNF113B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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