Seroatlas · Human Serome Atlas

RNASET2

Ribonuclease T2

Also known as: bA514O12.3, FLJ10907, RNASE6PL, RNT2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O00584
Gene
RNASET2
Ensembl
ENSG00000026297
Chromosome
6
Canonical length
256 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins
Secretome location
Secreted to blood

OverviewNCBI Gene

This ribonuclease gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

256 residues, UniProt reviewed canonical sequence.

>O00584|RNASET2
     1  MRPAALRGAL LGCLCLALLC LGGADKRLRD NHEWKKLIMV QHWPETVCEK IQNDCRDPPD
    61  YWTIHGLWPD KSEGCNRSWP FNLEEIKDLL PEMRAYWPDV IHSFPNRSRF WKHEWEKHGT
   121  CAAQVDALNS QKKYFGRSLE LYRELDLNSV LLKLGIKPSI NYYQVADFKD ALARVYGVIP
   181  KIQCLPPSQD EEVQTIGQIE LCLTKQDQQL QNCTEPGEQP SPKQEVWLAN GAAESRGLRV
   241  CEDGPVFYPP PKKTKH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNASET2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
165 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 165 nTPM
  • cervix: 150 nTPM
  • pancreas: 132 nTPM
  • epididymis: 131 nTPM
  • fallopian tube: 124 nTPM
  • choroid plexus: 112 nTPM

Single-cell type

  • endometrial luminal cells: 721 nCPM
  • endometrial glandular cells: 362 nCPM
  • pdcs: 353 nCPM
  • epididymal efferent duct absorptive cells: 332 nCPM
  • kupffer cells: 330 nCPM
  • neutrophils: 275 nCPM

Immune cell

  • eosinophil: 654 nTPM
  • neutrophil: 427 nTPM
  • non-classical monocyte: 359 nTPM
  • plasmacytoid DC: 357 nTPM
  • intermediate monocyte: 268 nTPM
  • myeloid DC: 218 nTPM

Brain region

  • white matter: 71 nTPM
  • medulla oblongata: 40 nTPM
  • spinal cord: 34 nTPM
  • pons: 28 nTPM
  • thalamus: 23 nTPM
  • midbrain: 22 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RNASET2.

Disease | AllUniProt

Conditions RNASET2 is implicated in, by any mechanism.

  • Leukoencephalopathy, cystic, without megalencephaly (LCWM) MIM:612951

Disease | GeneticClinVar

11 pathogenic / likely-pathogenic of 196 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.96
gnomAD pLI
0
gnomAD missense Z
0.24
DepMap mean gene effect
0
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Ribonuclease T2-like
  • Ribonuclease T2, His active site 1
  • Ribonuclease T2, His active site 2
  • Ribonuclease T2, eukaryotic
  • Ribonuclease T2-like superfamily
  • Ribonuclease T2 family

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNASET2 as an antibody target. Whether an autoantibody or antibody against RNASET2 could matter depends on whether native RNASET2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNASET2 is annotated as secreted, so native RNASET2 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label RNASET2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RNASET2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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