RNASEK
Ribonuclease kappa
Also known as: MGC71993, RNK_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6P5S7
- Gene
- RNASEK
- Ensembl
- ENSG00000219200
- Chromosome
- 17
- Canonical length
- 137 aa
- Protein class
- Predicted intracellular proteins, Predicted membrane proteins, Transporters
OverviewNCBI Gene
Enables RNA endonuclease activity. Involved in endosomal lumen acidification; proton transmembrane transport; and receptor-mediated endocytosis of virus by host cell. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
137 residues, UniProt reviewed canonical sequence.
>Q6P5S7|RNASEK
1 MGWLRPGPRP LCPPARASWA FSHRFPSPLA PRRSPTPFFM ASLLCCGPKL AACGIVLSAW
61 GVIMLIMLGI FFNVHSAVLI EDVPFTEKDF ENGPQNIYNL YEQVSYNCFI AAGLYLLLGG
121 FSFCQVRLNK RKEYMVRLocalizationUniProt · AlphaFold · HPA
Whether an antibody against RNASEK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 2
- Mean surface accessibility (rSASA)
- 0.51
- Highest tissue expression
- 685 nTPM
Expression across tissuesHPA
Tissue
- choroid plexus: 685 nTPM
- adrenal gland: 539 nTPM
- kidney: 469 nTPM
- pituitary gland: 460 nTPM
- hypothalamus: 449 nTPM
- cerebral cortex: 391 nTPM
Single-cell type
- other brain neurons: 194 nCPM
- brain inhibitory neurons: 95 nCPM
- brain excitatory neurons: 91 nCPM
- oligodendrocytes: 87 nCPM
- microglia: 82 nCPM
- oligodendrocyte progenitor cells: 63 nCPM
Immune cell
- neutrophil: 2,190 nTPM
- eosinophil: 1,383 nTPM
- classical monocyte: 1,141 nTPM
- plasmacytoid DC: 1,074 nTPM
- total PBMC: 1,054 nTPM
- intermediate monocyte: 1,034 nTPM
Brain region
- hypothalamus: 411 nTPM
- choroid plexus: 324 nTPM
- pons: 293 nTPM
- midbrain: 257 nTPM
- medulla oblongata: 255 nTPM
- cerebral cortex: 245 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.78
- gnomAD pLI
- 0.5
- gnomAD missense Z
- 0.5
- DepMap mean gene effect
- -0.53
- DepMap dependency class
- common
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- endosomal lumen acidification
- Golgi lumen acidification
- intracellular pH reduction
- lysosomal lumen acidification
- proton transmembrane transport
- receptor-mediated endocytosis
- receptor-mediated endocytosis of virus by host cell
- vacuolar acidification
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Ribonuclease kappa
- V-type proton ATPase subunit f-like
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of RNASEK in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads RNASEK as an antibody target. Whether an autoantibody or antibody against RNASEK could matter depends on whether native RNASEK is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
RNASEK is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label RNASEK as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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