RNASE12
Probable inactive ribonuclease-like protein 12
Also known as: RAI1, RNS12_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q5GAN4
- Gene
- RNASE12
- Ensembl
- ENSG00000258436
- Chromosome
- 14
- Canonical length
- 147 aa
- Protein class
- Predicted secreted proteins
- Secretome location
- Secreted in male reproductive system
OverviewNCBI Gene
Predicted to enable RNA nuclease activity. Predicted to be involved in defense response to Gram-positive bacterium. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
147 residues, UniProt reviewed canonical sequence.
>Q5GAN4|RNASE12
1 MIIMVIIFLV LLFWENEVND EAVMSTLEHL HVDYPQNDVP VPARYCNHMI IQRVIREPDH
61 TCKKEHVFIH ERPRKINGIC ISPKKVACQN LSAIFCFQSE TKFKMTVCQL IEGTRYPACR
121 YHYSPTEGFV LVTCDDLRPD SFLGYVKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against RNASE12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.36
- Highest tissue expression
- 657 nTPM
Expression across tissuesHPA
Tissue
- epididymis: 657 nTPM
- seminal vesicle: 2.3 nTPM
- breast: 1.4 nTPM
- testis: 1.2 nTPM
- bone marrow: 0.2 nTPM
- placenta: 0.1 nTPM
Single-cell type
- epididymal clear cells: 2 nCPM
- epididymal principal cells: 1.4 nCPM
- epididymal basal cells: 0.3 nCPM
- epididymal efferent duct absorptive cells: 0.2 nCPM
- vascular smooth muscle cells: 0.1 nCPM
- adipocytes: 0 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- cerebral cortex: 0 nTPM
- choroid plexus: 0 nTPM
- hippocampal formation: 0 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.81
- gnomAD pLI
- 0.01
- gnomAD missense Z
- -0.03
- DepMap mean gene effect
- 0.1
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads RNASE12 as an antibody target. Whether an autoantibody or antibody against RNASE12 could matter depends on whether native RNASE12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
RNASE12 is annotated as secreted, so native RNASE12 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label RNASE12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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