Seroatlas · Human Serome Atlas

RNASE11

Putative inactive ribonuclease 11

Also known as: C14orf6, RAJ1, RNS11_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TAA1
Gene: RNASE11
Ensembl: ENSG00000173464
Chromosome: 14
Canonical length: 199 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted in male reproductive system

OverviewNCBI Gene

Predicted to enable endonuclease activity and nucleic acid binding activity. Predicted to be involved in defense response to Gram-positive bacterium. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

199 residues, UniProt reviewed canonical sequence.

>Q8TAA1|RNASE11
     1  METFPLLLLS LGLVLAEASE STMKIIKEEF TDEEMQYDMA KSGQEKQTIE ILMNPILLVK
    61  NTSLSMSKDD MSSTLLTFRS LHYNDPKGNS SGNDKECCND MTVWRKVSEA NGSCKWSNNF
   121  IRSSTEVMRR VHRAPSCKFV QNPGISCCES LELENTVCQF TTGKQFPRCQ YHSVTSLEKI
   181  LTVLTGHSLM SWLVCGSKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNASE11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 622 nTPM

Expression across tissuesHPA

Tissue

epididymis: 622 nTPM
testis: 44 nTPM
seminal vesicle: 0.5 nTPM
placenta: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM

Single-cell type

late spermatids: 54 nCPM
early spermatids: 25 nCPM
epididymal principal cells: 19 nCPM
late primary spermatocytes: 4.7 nCPM
epididymal efferent duct ciliated cells: 0.4 nCPM
early primary spermatocytes: 0.1 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.9
gnomAD pLI: 0.02
gnomAD missense Z: -0.06
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNASE11 as an antibody target. Whether an autoantibody or antibody against RNASE11 could matter depends on whether native RNASE11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNASE11 is annotated as secreted, so native RNASE11 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label RNASE11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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