Seroatlas · Human Serome Atlas

RNASE10

Inactive ribonuclease-like protein 10

Also known as: RAH1, RNASE9, RNS10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5GAN6
Gene: RNASE10
Ensembl: ENSG00000182545
Chromosome: 14
Canonical length: 216 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted - unknown location

OverviewNCBI Gene

Predicted to enable nucleic acid binding activity. Predicted to be involved in several processes, including defense response to Gram-positive bacterium; positive regulation of flagellated sperm motility; and regulation of fertilization. Predicted to act upstream of or within epithelial cell morphogenesis; seminiferous tubule development; and single fertilization. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

216 residues, UniProt reviewed canonical sequence.

>Q5GAN6|RNASE10
     1  MKLNLVQIFF MLLMLLLGLG MGLGLGLHMA TAVLEESDQP LNEFWSSDSQ DKAEATEEGD
    61  GTQTTETLVL SNKEVVQPGW PEDPILGEDE VGGNKMLRAS ALFQSNKDYL RLDQTDRECN
   121  DMMAHKMKEP SQSCIAQYAF IHEDLNTVKA VCNSPVIACE LKGGKCHKSS RPFDLTLCEL
   181  SQPDQVTPNC NYLTSVIKKH IIITCNDMKR QLPTGQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNASE10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 0.8 nTPM

Expression across tissuesHPA

Tissue

liver: 0.8 nTPM
testis: 0.8 nTPM
adrenal gland: 0.7 nTPM
fallopian tube: 0.7 nTPM
kidney: 0.7 nTPM
ovary: 0.7 nTPM

Single-cell type

renal collecting duct principal cells: 13 nCPM
papillary tip epithelial cells: 8.6 nCPM
loop of henle epithelial cells: 4.6 nCPM
renal collecting duct intercalated cells: 4 nCPM
distal convoluted tubule cells: 3.9 nCPM
renal connecting tubule cells: 3.5 nCPM

Immune cell

basophil: 0.2 nTPM
neutrophil: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebral cortex: 4.3 nTPM
white matter: 4.2 nTPM
medulla oblongata: 3.8 nTPM
pons: 3.8 nTPM
amygdala: 3.7 nTPM
hippocampal formation: 3.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.8
gnomAD pLI: 0
gnomAD missense Z: -0.65
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

nucleic acid binding

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNASE10 as an antibody target. Whether an autoantibody or antibody against RNASE10 could matter depends on whether native RNASE10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNASE10 is annotated as secreted, so native RNASE10 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label RNASE10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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