Seroatlas · Human Serome Atlas

RMC1

Regulator of MON1-CCZ1 complex

Also known as: C18orf8, HsT2591, MIC1, RMC1_HUMAN, WDR98

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96DM3
Gene
RMC1
Ensembl
ENSG00000141452
Chromosome
18
Canonical length
657 aa
Protein class
Cancer-related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

This gene encodes a colon cancer associated protein. [provided by RefSeq, Jan 2013]

Canonical amino-acid sequenceUniProt

657 residues, UniProt reviewed canonical sequence.

>Q96DM3|RMC1
     1  MGEEDYYLEL CERPVQFEKA NPVNCVFFDE ANKQVFAVRS GGATGVVVKG PDDRNPISFR
    61  MDDKGEVKCI KFSLENKILA VQRTSKTVDF CNFIPDNSQL EYTQECKTKN ANILGFCWTS
   121  STEIVFITDQ GIEFYQVLPE KRSLKLLKSH NLNVNWYMYC PESAVILLST TVLENVLQPF
   181  HFRAGTMSKL PKFEIELPAA PKSTKPSLSE RDIAMATIYG QLYVLFLRHH SRTSNSTGAE
   241  VVLYHLPREG ACKKMHILKL NRTGKFALNV VDNLVVVHHQ DTETSVIFDI KLRGEFDGSV
   301  TFHHPVLPAR SIQPYQIPIT GPAAVTSQSP VPCKLYSSSW IVFQPDIIIS ASQGYLWNLQ
   361  VKLEPIVNLL PDKGRLMDFL LQRKECKMVI LSVCSQMLSE SDRASLPVIA TVFDKLNHEY
   421  KKYLDAEQSY AMAVEAGQSR SSPLLKRPVR TQAVLDQSDV YTHVLSAFVE KKEMPHKFVI
   481  AVLMEYIRSL NQFQIAVQHY LHELVIKTLV QHNLFYMLHQ FLQYHVLSDS KPLACLLLSL
   541  ESFYPPAHQL SLDMLKRLST ANDEIVEVLL SKHQVLAALR FIRGIGGHDN ISARKFLDAA
   601  KQTEDNMLFY TIFRFFEQRN QRLRGSPNFT PGEHCEEHVA FFKQIFGDQA LMRPTTF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RMC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
26 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 26 nTPM
  • retina: 24 nTPM
  • lymph node: 20 nTPM
  • liver: 18 nTPM
  • tonsil: 18 nTPM
  • small intestine: 16 nTPM

Single-cell type

  • epididymal basal cells: 181 nCPM
  • rod photoreceptor cells: 102 nCPM
  • endometrial glandular cells: 101 nCPM
  • epididymal clear cells: 94 nCPM
  • epicardial cells: 80 nCPM
  • cone photoreceptor cells: 77 nCPM

Immune cell

  • basophil: 51 nTPM
  • non-classical monocyte: 45 nTPM
  • plasmacytoid DC: 45 nTPM
  • eosinophil: 38 nTPM
  • NK-cell: 33 nTPM
  • memory B-cell: 33 nTPM

Brain region

  • choroid plexus: 15 nTPM
  • white matter: 12 nTPM
  • cerebral cortex: 11 nTPM
  • hypothalamus: 11 nTPM
  • pons: 8.7 nTPM
  • basal ganglia: 8.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.3
gnomAD pLI
0.99
DepMap mean gene effect
0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RMC1 as an antibody target. Whether an autoantibody or antibody against RMC1 could matter depends on whether native RMC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RMC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RMC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RMC1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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