Seroatlas · Human Serome Atlas

RLIG1

RNA ligase 1

Also known as: C12orf29, DKFZp434N2030, RLIG1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N999
Gene: RLIG1
Ensembl: ENSG00000133641
Chromosome: 12
Canonical length: 325 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Enables RNA ligase (ATP) activity. Involved in response to reactive oxygen species. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

325 residues, UniProt reviewed canonical sequence.

>Q8N999|RLIG1
     1  MKRLGSVQRK MPCVFVTEVK EEPSSKREHQ PFKVLATETV SHKALDADIY SAIPTEKVDG
    61  TCCYVTTYKD QPYLWARLDR KPNKQAEKRF KNFLHSKENP KEFFWNVEED FKPAPECWIP
   121  AKETEQINGN PVPDENGHIP GWVPVEKNNK QYCWHSSVVN YEFEIALVLK HHPDDSGLLE
   181  ISAVPLSDLL EQTLELIGTN INGNPYGLGS KKHPLHLLIP HGAFQIRNLP SLKHNDLVSW
   241  FEDCKEGKIE GIVWHCSDGC LIKVHRHHLG LCWPIPDTYM NSRPVIINMN LNKCDSAFDI
   301  KCLFNHFLKI DNQKFVRLKD IIFDV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RLIG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

esophagus: 15 nTPM
skin: 15 nTPM
epididymis: 12 nTPM
liver: 12 nTPM
breast: 10 nTPM
cerebral cortex: 9.4 nTPM

Single-cell type

esophageal apical cells: 460 nCPM
oocytes: 157 nCPM
esophageal suprabasal cells: 120 nCPM
suprabasal keratinocytes: 79 nCPM
late primary spermatocytes: 54 nCPM
early spermatids: 53 nCPM

Immune cell

MAIT T-cell: 4.9 nTPM
naive CD4 T-cell: 4.6 nTPM
basophil: 4.5 nTPM
memory CD4 T-cell: 3.9 nTPM
naive CD8 T-cell: 3.9 nTPM
NK-cell: 3.4 nTPM

Brain region

cerebral cortex: 9.6 nTPM
white matter: 9.6 nTPM
basal ganglia: 8 nTPM
midbrain: 8 nTPM
hypothalamus: 7.9 nTPM
spinal cord: 7.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.36
gnomAD pLI: 0
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ATP binding
RNA ligase (ATP) activity

Protein domainsUniProt · Pfam · InterPro

RNA ligase 1
RNA ligase 1

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RLIG1 as an antibody target. Whether an autoantibody or antibody against RLIG1 could matter depends on whether native RLIG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RLIG1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RLIG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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