Seroatlas · Human Serome Atlas

RITA1

RBPJ-interacting and tubulin-associated protein 1

Also known as: C12orf52, FLJ14827, RITA, RITA1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96K30
Gene: RITA1
Ensembl: ENSG00000139405
Chromosome: 12
Canonical length: 269 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables tubulin binding activity. Involved in negative regulation of Notch signaling pathway and nuclear export. Located in centrosome; cytoplasm; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

269 residues, UniProt reviewed canonical sequence.

>Q96K30|RITA1
     1  MKTPVELAVS GMQTLGLQHR CRGGYRVKAR TSYVDETLFG SPAGTRPTPP DFDPPWVEKA
    61  NRTRGVGKEA SKALGAKGSC ETTPSRGSTP TLTPRKKNKY RPISHTPSYC DESLFGSRSE
   121  GASFGAPRMA KGDAAKLRAL LWTPPPTPRG SHSPRPREAP LRAIHPAGPS KTEPGPAADS
   181  QKLSMGGLHS SRPLKRGLSH SLTHLNVPST GHPATSAPHT NGPQDLRPST SGVTFRSPLV
   241  TSRARSVSIS VPSTPRRGGA TQKPKPPWK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RITA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.72
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

liver: 32 nTPM
skeletal muscle: 30 nTPM
adrenal gland: 26 nTPM
tongue: 26 nTPM
cerebral cortex: 23 nTPM
choroid plexus: 19 nTPM

Single-cell type

enterocytes: 58 nCPM
late spermatids: 46 nCPM
hepatocytes: 44 nCPM
esophageal suprabasal cells: 38 nCPM
esophageal apical cells: 38 nCPM
respiratory ciliated cells: 32 nCPM

Immune cell

basophil: 44 nTPM
plasmacytoid DC: 23 nTPM
NK-cell: 21 nTPM
myeloid DC: 17 nTPM
T-reg: 16 nTPM
gdT-cell: 15 nTPM

Brain region

cerebral cortex: 30 nTPM
hippocampal formation: 29 nTPM
basal ganglia: 28 nTPM
hypothalamus: 28 nTPM
amygdala: 27 nTPM
thalamus: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.61
gnomAD pLI: 0
gnomAD missense Z: 0.45
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

tubulin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

RBPJ-interacting and tubulin-associated protein 1
RBPJ-interacting and tubulin associated protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RITA1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

RBPJ

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RITA1 as an antibody target. Whether an autoantibody or antibody against RITA1 could matter depends on whether native RITA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RITA1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RITA1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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