Seroatlas · Human Serome Atlas

RIOX2

Ribosomal oxygenase 2

Also known as: FLJ14393, JMJD10, mdig, MINA, MINA53, NO52, RIOX2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IUF8
Gene: RIOX2
Ensembl: ENSG00000170854
Chromosome: 3
Canonical length: 465 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

MINA is a c-Myc (MYC; MIM 190080) target gene that may play a role in cell proliferation or regulation of cell growth. (Tsuneoka et al., 2002 [PubMed 12091391]; Zhang et al., 2005 [PubMed 15897898]).[supplied by OMIM, May 2008]

Canonical amino-acid sequenceUniProt

465 residues, UniProt reviewed canonical sequence.

>Q8IUF8|RIOX2
     1  MPKKAKPTGS GKEEGPAPCK QMKLEAAGGP SALNFDSPSS LFESLISPIK TETFFKEFWE
    61  QKPLLIQRDD PALATYYGSL FKLTDLKSLC SRGMYYGRDV NVCRCVNGKK KVLNKDGKAH
   121  FLQLRKDFDQ KRATIQFHQP QRFKDELWRI QEKLECYFGS LVGSNVYITP AGSQGLPPHY
   181  DDVEVFILQL EGEKHWRLYH PTVPLAREYS VEAEERIGRP VHEFMLKPGD LLYFPRGTIH
   241  QADTPAGLAH STHVTISTYQ NNSWGDFLLD TISGLVFDTA KEDVELRTGI PRQLLLQVES
   301  TTVATRRLSG FLRTLADRLE GTKELLSSDM KKDFIMHRLP PYSAGDGAEL STPGGKLPRL
   361  DSVVRLQFKD HIVLTVLPDQ DQSDEAQEKM VYIYHSLKNS RETHMMGNEE ETEFHGLRFP
   421  LSHLDALKQI WNSPAISVKD LKLTTDEEKE SLVLSLWTEC LIQVV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RIOX2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 43 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 43 nTPM
skeletal muscle: 25 nTPM
esophagus: 18 nTPM
skin: 17 nTPM
salivary gland: 17 nTPM
spinal cord: 16 nTPM

Single-cell type

extravillous trophoblasts: 71 nCPM
esophageal apical cells: 68 nCPM
breast lactating cells: 56 nCPM
epicardial cells: 55 nCPM
migrating cytotrophoblasts: 54 nCPM
retinal bipolar cells: 53 nCPM

Immune cell

plasmacytoid DC: 26 nTPM
myeloid DC: 17 nTPM
memory B-cell: 16 nTPM
non-classical monocyte: 16 nTPM
MAIT T-cell: 16 nTPM
T-reg: 15 nTPM

Brain region

white matter: 25 nTPM
spinal cord: 24 nTPM
medulla oblongata: 24 nTPM
hypothalamus: 24 nTPM
midbrain: 24 nTPM
pons: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.07
gnomAD pLI: 0
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

ribosome biogenesis

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

JmjC domain
Histone lysine demethylase/ribosomal histidine hydroxylase NO66-like
JmjC domain
ROXA-like, winged helix
ROXA-like winged helix

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RIOX2 as an antibody target. Whether an autoantibody or antibody against RIOX2 could matter depends on whether native RIOX2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RIOX2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RIOX2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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