Seroatlas · Human Serome Atlas

RIMBP2

RIMS-binding protein 2

Also known as: KIAA0318, MGC15831, PPP1R133, RBP2, RIM-BP2, RIMB2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O15034
Gene
RIMBP2
Ensembl
ENSG00000060709
Chromosome
12
Canonical length
1052 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Golgi apparatus,Cytosol

OverviewNCBI Gene

Predicted to enable voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels and voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential. Predicted to be a structural constituent of presynaptic active zone. Predicted to be involved in neuromuscular synaptic transmission; regulation of calcium-dependent activation of synaptic vesicle fusion; and regulation of presynaptic membrane potential. Predicted to be located in plasma membrane and synapse. Predicted to be active in calyx of Held; glutamatergic synapse; and presynaptic active zone cytoplasmic component. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1052 residues, UniProt reviewed canonical sequence.

>O15034|RIMBP2
     1  MREAAERRQQ LQLEHDQALA VLSAKQQEID LLQKSKVREL EEKCRTQSEQ FNLLSRDLEK
    61  FRQHAGKIDL LGGSAVAPLD ISTAPSKPFP QFMNGLATSL GKGQESAIGG SSAIGEYIRP
   121  LPQPGDRPEP LSAKPTFLSR SGSARCRSES DMENERNSNT SKQRYSGKVH LCVARYSYNP
   181  FDGPNENPEA ELPLTAGKYL YVYGDMDEDG FYEGELLDGQ RGLVPSNFVD FVQDNESRLA
   241  STLGNEQDQN FINHSGIGLE GEHILDLHSP THIDAGITDN SAGTLDVNID DIGEDIVPYP
   301  RKITLIKQLA KSVIVGWEPP AVPPGWGTVS SYNVLVDKET RMNLTLGSRT KALIEKLNMA
   361  ACTYRISVQC VTSRGSSDEL QCTLLVGKDV VVAPSHLRVD NITQISAQLS WLPTNSNYSH
   421  VIFLNEEEFD IVKAARYKYQ FFNLRPNMAY KVKVLAKPHQ MPWQLPLEQR EKKEAFVEFS
   481  TLPAGPPAPP QDVTVQAGVT PATIRVSWRP PVLTPTGLSN GANVTGYGVY AKGQRVAEVI
   541  FPTADSTAVE LVRLRSLEAK GVTVRTLSAQ GESVDSAVAA VPPELLVPPT PHPRPAPQSK
   601  PLASSGVPET KDEHLGPHAR MDEAWEQSRA PGPVHGHMLE PPVGPGRRSP SPSRILPQPQ
   661  GTPVSTTVAK AMAREAAQRV AESSRLEKRS VFLERSSAGQ YAASDEEDAY DSPDFKRRGA
   721  SVDDFLKGSE LGKQPHCCHG DEYHTESSRG SDLSDIMEED EEELYSEMQL EDGGRRRPSG
   781  TSHNALKILG NPASAGRVDH MGRRFPRGSA GPQRSRPVTV PSIDDYGRDR LSPDFYEESE
   841  TDPGAEELPA RIFVALFDYD PLTMSPNPDA AEEELPFKEG QIIKVYGDKD ADGFYRGETC
   901  ARLGLIPCNM VSEIQADDEE MMDQLLRQGF LPLNTPVEKI ERSRRSGRRH SVSTRRMVAL
   961  YDYDPRESSP NVDVEAELTF CTGDIITVFG EIDEDGFYYG ELNGQKGLVP SNFLEEVPDD
  1021  VEVYLSDAPS HYSQDTPMRS KAKRKKSVHF TP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RIMBP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
28 nTPM

Expression across tissuesHPA

Tissue

  • pituitary gland: 28 nTPM
  • parathyroid gland: 21 nTPM
  • cerebral cortex: 19 nTPM
  • adrenal gland: 13 nTPM
  • choroid plexus: 12 nTPM
  • retina: 10 nTPM

Single-cell type

  • somatotrophs: 1,601 nCPM
  • lactotrophs: 858 nCPM
  • thyrotrophs: 527 nCPM
  • neuroendocrine cells: 475 nCPM
  • choroid plexus epithelial cells: 454 nCPM
  • adrenal medulla cells: 309 nCPM

Immune cell

  • naive B-cell: 0.4 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • hippocampal formation: 75 nTPM
  • pons: 67 nTPM
  • midbrain: 64 nTPM
  • hypothalamus: 62 nTPM
  • cerebral cortex: 60 nTPM
  • choroid plexus: 54 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.36
gnomAD pLI
0.68
gnomAD missense Z
1.34
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RIMBP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RIMBP2 as an antibody target. Whether an autoantibody or antibody against RIMBP2 could matter depends on whether native RIMBP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RIMBP2 is annotated at the cell surface, where native RIMBP2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RIMBP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RIMBP2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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