Seroatlas · Human Serome Atlas

RIIAD1

RIIa domain-containing protein 1

Also known as: C1orf230, FLJ36032, NCRNA00166, RIAD1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6NNX1
Gene
RIIAD1
Ensembl
ENSG00000178796
Chromosome
1
Canonical length
92 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

No narrative summary is available for RIIAD1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

92 residues, UniProt reviewed canonical sequence.

>A6NNX1|RIIAD1
     1  METLPGLLQR PDPGALSAAQ LEQLRKFKIQ TRIANEKYLR THKEVEWLIS GFFREIFLKR
    61  PDNILEFAAD YFTDPRLPNK IHMQLIKDKK AA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RIIAD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
23 nTPM

Expression across tissuesHPA

Tissue

  • fallopian tube: 23 nTPM
  • pituitary gland: 13 nTPM
  • testis: 8.4 nTPM
  • basal ganglia: 5.3 nTPM
  • retina: 4.5 nTPM
  • hypothalamus: 4.1 nTPM

Single-cell type

  • fallopian tube ciliated cells: 273 nCPM
  • respiratory ciliated cells: 236 nCPM
  • epididymal efferent duct ciliated cells: 230 nCPM
  • endometrial ciliated cells: 151 nCPM
  • late primary spermatocytes: 108 nCPM
  • cone photoreceptor cells: 81 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebellum: 10 nTPM
  • basal ganglia: 8.1 nTPM
  • cerebral cortex: 8 nTPM
  • hypothalamus: 8 nTPM
  • hippocampal formation: 7.3 nTPM
  • amygdala: 6.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.91
gnomAD pLI
0
gnomAD missense Z
0.63
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RIIAD1 as an antibody target. Whether an autoantibody or antibody against RIIAD1 could matter depends on whether native RIIAD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RIIAD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RIIAD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RIIAD1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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