Seroatlas · Human Serome Atlas

RIC8B

Chaperone Ric-8B

Also known as: FLJ10620, hSyn, RIC8, RIC8B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NVN3
Gene: RIC8B
Ensembl: ENSG00000111785
Chromosome: 12
Canonical length: 520 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

Enables G-protein alpha-subunit binding activity. Acts upstream of or within regulation of G protein-coupled receptor signaling pathway. Located in centrosome; cytosol; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

520 residues, UniProt reviewed canonical sequence.

>Q9NVN3|RIC8B
     1  MDEERALYIV RAGEAGAIER VLRDYSDKHR ATFKFESTDE DKRKKLCEGI FKVLIKDIPT
    61  TCQVSCLEVL RILSRDKKVL VPVTTKENMQ ILLRLAKLNE LDDSLEKVSE FPVIVESLKC
   121  LCNIVFNSQM AQQLSLELNL AAKLCNLLRK CKDRKFINDI KCFDLRLLFL LSLLHTDIRS
   181  QLRYELQGLP LLTQILESAF SIKWTDEYES AIDHNGPPLS PQETDCAIEA LKALFNVTVD
   241  SWKVHKESDS HQFRVMAAVL RHCLLIVGPT EDKTEELHSN AVNLLSNVPV SCLDVLICPL
   301  THEETAQEAT TLDELPSNKT AEKETVLKNN TMVYNGMNME AIHVLLNFME KRIDKGSSYR
   361  EGLTPVLSLL TECSRAHRNI RKFLKDQVLP PLRDVTNRPE VGSTVRNKLV RLMTHVDLGV
   421  KQIAAEFLFV LCKERVDSLL KYTGYGNAAG LLAARGLLAG GRGDNWYSED EDTDTEEYKN
   481  AKPKEELLKP MGLKPDGTIT PLEEALNQYS VIEETSSDTD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RIC8B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 20 nTPM
retina: 12 nTPM
parathyroid gland: 11 nTPM
cerebellum: 10 nTPM
thyroid gland: 8.7 nTPM
heart muscle: 8.2 nTPM

Single-cell type

brain inhibitory neurons: 320 nCPM
choroid plexus epithelial cells: 201 nCPM
ependymal cells: 180 nCPM
cardiomyocytes: 164 nCPM
rod photoreceptor cells: 159 nCPM
pancreatic duct cells: 155 nCPM

Immune cell

MAIT T-cell: 2.2 nTPM
gdT-cell: 1.9 nTPM
classical monocyte: 1.4 nTPM
myeloid DC: 1.3 nTPM
eosinophil: 1.2 nTPM
T-reg: 1.1 nTPM

Brain region

basal ganglia: 58 nTPM
midbrain: 28 nTPM
hypothalamus: 23 nTPM
cerebral cortex: 22 nTPM
white matter: 20 nTPM
cerebellum: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.2
gnomAD pLI: 1
gnomAD missense Z: 2
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RIC8B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RIC8B as an antibody target. Whether an autoantibody or antibody against RIC8B could matter depends on whether native RIC8B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RIC8B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RIC8B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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