Seroatlas · Human Serome Atlas

RIBC2

RIB43A-like with coiled-coils protein 2

Also known as: C22orf11, DKFZp566F0546, FLJ25720, RIBC2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H4K1
Gene: RIBC2
Ensembl: ENSG00000128408
Chromosome: 22
Canonical length: 382 aa
Protein class: Predicted intracellular proteins
Subcellular location: Perinuclear theca,Calyx,Connecting piece,Mid piece,Principal piece,End piece

OverviewNCBI Gene

Predicted to be involved in flagellated sperm motility. Located in axonemal microtubule. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

382 residues, UniProt reviewed canonical sequence.

>Q9H4K1|RIBC2
     1  MGSQTMAVAL PRDLRQDANL AKRRHAELCR QKRVFNARNR IIGGDTEAWD VQVHDQKIKE
    61  ATEKARHETF AAEMRQNDKI MCILENRKKR DRKNLCRAIN DFQQSFQKPE TRREFDLSDP
   121  LALKKDLPAR QSDNDVRNTI SGMQKFMGED LNFHERKKFQ EEQNREWSLQ QQREWKNARA
   181  EQKCAEALYT ETRLQFDETA KHLQKLESTT RKAVCASVKD FNKSQAIESV ERKKQEKKQE
   241  QEDNLAEITN LLRGDLLSEN PQQAASSFGP HRVVPDRWKG MTQEQLEQIR LVQKQQIQEK
   301  LRLQEEKRQR DLDWDRRRIQ GARATLLFER QQWRRQRDLR RALDSSNLSL AKEQHLQKKY
   361  MNEVYTNQPT GDYFTQFNTG SR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RIBC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

testis: 29 nTPM
choroid plexus: 13 nTPM
fallopian tube: 9.2 nTPM
bone marrow: 1.8 nTPM
pituitary gland: 1.3 nTPM
basal ganglia: 1.2 nTPM

Single-cell type

late primary spermatocytes: 382 nCPM
early spermatids: 169 nCPM
respiratory ciliated cells: 110 nCPM
endometrial ciliated cells: 99 nCPM
fallopian tube ciliated cells: 93 nCPM
epididymal efferent duct ciliated cells: 90 nCPM

Immune cell

myeloid DC: 0.3 nTPM
memory CD8 T-cell: 0.2 nTPM
T-reg: 0.2 nTPM
classical monocyte: 0.1 nTPM
memory B-cell: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM

Brain region

choroid plexus: 31 nTPM
medulla oblongata: 6.1 nTPM
midbrain: 6.1 nTPM
white matter: 5.3 nTPM
spinal cord: 3.8 nTPM
amygdala: 2.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.48
gnomAD pLI: 0
gnomAD missense Z: 0.37

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

flagellated sperm motility

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RIBC2 as an antibody target. Whether an autoantibody or antibody against RIBC2 could matter depends on whether native RIBC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RIBC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RIBC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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