Seroatlas · Human Serome Atlas

RHPN2P1

Putative rhophilin-2-like protein RHPN2P1

Also known as: RHN2P_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A8MT19
Gene: RHPN2P1
Canonical length: 583 aa

OverviewNCBI Gene

No narrative summary is available for RHPN2P1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

583 residues, UniProt reviewed canonical sequence.

>A8MT19|RHPN2P1
     1  MLKEELEGLN ISVGIYQNTE EAFTVPLIPL GLKETKDIDF SVILKDFILE HYSEDGYLYE
    61  DEITDLMDPR QACRTPSRDE ARVELLMTYF IQLGFAWIRF KKYNTSPRIF FYRYDSLNGV
   121  LVSQQNLLLE KASVLFNTGA LYTQIGTWRY WQMQAGLQSA IDAFQRAAGV LNYLKETFTH
   181  TPSYDMSPAM LSVLVKMMLT QAQESVFEKI SLPGIRNEFF MLVKVAQEAA KVGEVYQQLH
   241  AAMSQALVKE NIPYSWASLA CVKAHHYTAL AHYFTAILLI DHQVKPGMDL DHQEKCLSQL
   301  YDHMPEGLTP LATLKNDQQR RQLGKSHLHR AMAHHEESVR EASLCKKLRS IEVLQKVLCA
   361  AQERSRLTYA QHQEDDDLLN LIHAPSVVAK TEQEPKGPLS VFLANKQWMP PRSNRFTAEE
   421  GDLGFTLRGN APVEVHFLDP YCSALVAGAR GGDYIVSIQL VDCKWLTVSE VMKLLKSFGE
   481  DEIEMKVVSL LDSTSSMHNK SATYSVGMQK TYSMICLAID DDNKTDKTQK ISKKLSFLSW
   541  GTNKNRQKSA STLCLPSVGA ARPQVKKKLP SPFSLLNSDS SSY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RHPN2P1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32

OntologyGO

Biological processes

negative regulation of stress fiber assembly

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RHPN2P1 as an antibody target. Whether an autoantibody or antibody against RHPN2P1 could matter depends on whether native RHPN2P1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RHPN2P1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RHPN2P1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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