RHOXF2B

Protein identityUniProt · HPA

UniProt accession

P0C7M4

Gene

RHOXF2B

Ensembl

ENSG00000203989

Chromosome

X

Canonical length

288 aa

Protein class

Predicted intracellular proteins, Transcription factors

Subcellular location

Nucleoplasm,Plasma membrane

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in positive regulation of gene expression. Predicted to be located in chromatin. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

288 residues, UniProt reviewed canonical sequence.

>P0C7M4|RHOXF2B
     1  MEPPDQCSQY MTSLLSPAVD DEKELQDMNA MVLSLTEEVK EEEEDAQPEP EQGTAAGEKL
    61  KSAGAQGGEE KDGGGEEKDG GGAGVPGHLW EGNLEGTSGS DGNVEDSDQS EKEPGQQYSR
   121  PQGAVGGLEP GNAQQPNVHA FTPLQLQELE CIFQREQFPS EFLRRRLARS MNVTELAVQI
   181  WFENRRAKWR RHQRALMARN MLPFMAVGQP VMVTAAEAIT APLFISGMRD DYFWDHSHSS
   241  SLCFPMPPFP PPSLPLPLML LPPMPPAGQA EFGPFPFVIV PSFTFPNV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RHOXF2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.64

Highest tissue expression

28 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.34

gnomAD pLI

0.25

gnomAD missense Z

-0.07

DepMap mean gene effect

-0.05

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• neuron development
• positive regulation of gene expression
• regulation of transcription by RNA polymerase II

Molecular functions

• DNA-binding transcription factor activity, RNA polymerase II-specific
• RNA polymerase II transcription regulatory region sequence-specific DNA binding

Cellular components

• chromatin
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Homeodomain
• Homedomain-like superfamily
• Homeobox, conserved site
• Homeodomain

KeywordsUniProt

• DNA-binding
• Homeobox
• Nucleus