Seroatlas · Human Serome Atlas

RHEX

Regulator of hemoglobinization and erythroid cell expansion protein

Also known as: C1orf186, FLJ16052, RHEX_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZWK4
Gene: RHEX
Ensembl: ENSG00000263961
Chromosome: 1
Canonical length: 172 aa
Protein class: Predicted membrane proteins
Subcellular location: Plasma membrane

OverviewNCBI Gene

Enables erythropoietin receptor binding activity. Involved in erythropoietin-mediated signaling pathway and positive regulation of erythrocyte differentiation. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

172 residues, UniProt reviewed canonical sequence.

>Q6ZWK4|RHEX
     1  MLTEVMEVWH GLVIAVVSLF LQACFLTAIN YLLSRHMAHK SEQILKAASL QVPRPSPGHH
    61  HPPAVKEMKE TQTERDIPMS DSLYRHDSDT PSDSLDSSCS SPPACQATED VDYTQVVFSD
   121  PGELKNDSPL DYENIKEITD YVNVNPERHK PSFWYFVNPA LSEPAEYDQV AM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RHEX can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

cervix: 23 nTPM
seminal vesicle: 19 nTPM
epididymis: 15 nTPM
gallbladder: 15 nTPM
kidney: 14 nTPM
endometrium: 12 nTPM

Single-cell type

endometrial glandular cells: 1,237 nCPM
proximal tubule cells: 1,185 nCPM
endometrial luminal cells: 1,014 nCPM
mast cells: 699 nCPM
papillary tip epithelial cells: 637 nCPM
endometrial ciliated cells: 394 nCPM

Immune cell

basophil: 1,318 nTPM
eosinophil: 8.6 nTPM
total PBMC: 2 nTPM
plasmacytoid DC: 0.8 nTPM
myeloid DC: 0.6 nTPM
memory B-cell: 0.5 nTPM

Brain region

thalamus: 0.4 nTPM
cerebral cortex: 0.2 nTPM
midbrain: 0.2 nTPM
white matter: 0.2 nTPM
amygdala: 0.1 nTPM
basal ganglia: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.61
gnomAD pLI: 0
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

erythropoietin receptor binding

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

RHEX-like
Regulator of human erythroid cell expansion (RHEX)

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RHEX in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RHEX as an antibody target. Whether an autoantibody or antibody against RHEX could matter depends on whether native RHEX is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RHEX is annotated at the cell surface, where native RHEX is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RHEX as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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