Seroatlas · Human Serome Atlas

RGSL1

Regulator of G-protein signaling protein-like

Also known as: RGSL_HUMAN, RGSL2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A5PLK6
Gene: RGSL1
Ensembl: ENSG00000121446
Chromosome: 1
Canonical length: 1076 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1076 residues, UniProt reviewed canonical sequence.

>A5PLK6|RGSL1
     1  MSSAEIIGST NLIILLEDEV FADFFNTFLS LPVFGQTPFY TVENSQWSLW PEIPCNLIAK
    61  YKGLLTWLEK CRLPFFCKTN LCFHYILCQE FISFIKSPEG GEELVDFWIL AENILSIDEM
   121  DLEVRDYYLS LLLMLRATHL QEGSRVVTLC NMNIKSLLNL SIWHPNQSTT RREILSHMQK
   181  VALFKLQSYW LPNFYTHTKM TMAKEEACHG LMQEYETRLY SVCYTHIGGL PLNMSIKKCH
   241  HFQKRYSSRK AKRKMWQLVD PDSWSLEMDL KPDAIGMPLQ ETCPQEKVVI QMPSLKMASS
   301  KETRISSLEK DMHYAKISSM ENKAKSHLHM EAPFETKVST HLRTVIPIVN HSSKMTIQKA
   361  IKQSFSLGYI HLALCADACA GNPFRDHLKK LNLKVEIQLL DLWQDLQHFL SVLLNNKKNG
   421  NAIFRHLLGD RICELYLNEQ IGPCLPLKSQ TIQGLKELLP SGDVIPWIPK AQKEICKMLS
   481  PWYDEFLDEE DYWFLLFTTQ NRFISSRQHK REFIGKEENI LLYKRIQQSL ELSQALADMK
   541  EMDYRQWRKI ATEDLKQGGS LQVELTSPVF LTDITKMSFE ELCYKNPKMA IQKISDDYKI
   601  YCEKAPKIDF KMEIIKETKT VSRSNRKMSL LKRTLVRKPS MRPRNLTEVL LNTQHLEFFR
   661  EFLKERKAKI PLQFLTAVQK ISIETNEKIC KSLIENVIKT FFQGQLSPEE MLQCDAPIIK
   721  EIASMRHVTT STLLTLQGHV MKSIEEKWFK DYQDLFPPHH QEVEVQSEVQ ISSRKPSKIV
   781  STYLQESQKK GWMRMISFIR SFCKYRRFML NPSKRQEFED YLHQEMQNSK ENFTTAHNTS
   841  GRSAPPSTNV RSADQENGEI TLVKRRIFGH RIITVNFAIN DLYFFSEMEK FNDLVSSAHM
   901  LQVNRAYNEN DVILMRSKMN IIQKLFLNSD IPPKLRVNVP EFQKDAILAA ITEGYLDRSV
   961  FHGAIMSVFP VVMYFWKRFC FWKATRSYLQ YRGKKFKDRK SPPKSTDKYP FSSGGDNAIL
  1021  RFTLLRGIEW LQPQREAISS VQNSSSSKLT QPRLVVSAMQ LHPVQGQKLS YIKKEK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RGSL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 4.6 nTPM

Expression across tissuesHPA

Tissue

testis: 4.6 nTPM
epididymis: 1 nTPM
skin: 0.2 nTPM
endometrium: 0.1 nTPM
tonsil: 0.1 nTPM
adipose tissue: 0 nTPM

Single-cell type

early spermatids: 179 nCPM
late primary spermatocytes: 137 nCPM
late spermatids: 48 nCPM
epididymal principal cells: 4.9 nCPM
epicardial cells: 4.5 nCPM
neutrophils: 4 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 0.4 nTPM
cerebral cortex: 0.3 nTPM
amygdala: 0.2 nTPM
hypothalamus: 0.2 nTPM
pons: 0.2 nTPM
white matter: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.72
gnomAD pLI: 0
gnomAD missense Z: 2.07
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

RGS domain
RGS domain superfamily
RGS, subdomain 2
Regulator of G protein signaling domain
Regulator of G-protein signaling domain-containing protein

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RGSL1 as an antibody target. Whether an autoantibody or antibody against RGSL1 could matter depends on whether native RGSL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RGSL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RGSL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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