Seroatlas · Human Serome Atlas

RGS5

Regulator of G-protein signaling 5

Also known as: RGS5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O15539
Gene: RGS5
Ensembl: ENSG00000143248
Chromosome: 1
Canonical length: 181 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Cytosol

OverviewNCBI Gene

This locus represents naturally occurring readthrough transcription between the neighboring LOC127814295 (uncharacterized LOC127814295) and RGS5 (regulator of G-protein signaling 5) genes on chromosome 1. Some variants of the readthrough transcript encode novel proteins with unique N-termini. [provided by RefSeq, Nov 2022]

Canonical amino-acid sequenceUniProt

181 residues, UniProt reviewed canonical sequence.

>O15539|RGS5
     1  MCKGLAALPH SCLERAKEIK IKLGILLQKP DSVGDLVIPY NEKPEKPAKT QKTSLDEALQ
    61  WRDSLDKLLQ NNYGLASFKS FLKSEFSEEN LEFWIACEDY KKIKSPAKMA EKAKQIYEEF
   121  IQTEAPKEVN IDHFTKDITM KNLVEPSLSS FDMAQKRIHA LMEKDSLPRF VRSEFYQELI
   181  K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RGS5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 1,363 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 1,363 nTPM
adrenal gland: 295 nTPM
smooth muscle: 259 nTPM
heart muscle: 223 nTPM
tongue: 221 nTPM
seminal vesicle: 179 nTPM

Single-cell type

pericytes: 2,480 nCPM
vascular smooth muscle cells: 1,367 nCPM
adrenal medulla cells: 1,223 nCPM
smooth muscle cells: 204 nCPM
mucous neck cells: 173 nCPM
vascular endothelial cells: 97 nCPM

Immune cell

MAIT T-cell: 0.5 nTPM
memory B-cell: 0.5 nTPM
memory CD4 T-cell: 0.5 nTPM
naive CD4 T-cell: 0.4 nTPM
naive CD8 T-cell: 0.4 nTPM
memory CD8 T-cell: 0.2 nTPM

Brain region

pons: 165 nTPM
thalamus: 149 nTPM
medulla oblongata: 137 nTPM
hypothalamus: 130 nTPM
midbrain: 125 nTPM
basal ganglia: 121 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RGS5.

Disease | ImmuneIEDB

Conditions an epitope on RGS5 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.35
gnomAD pLI: 0
gnomAD missense Z: 0.15
DepMap mean gene effect: 0.18
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

RGS domain
RGS, subdomain 1/3
RGS domain superfamily
RGS, subdomain 2
Regulator of G protein signaling domain
Regulator of G-protein signalling 5, RGS domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RGS5 as an antibody target. Whether an autoantibody or antibody against RGS5 could matter depends on whether native RGS5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RGS5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RGS5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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