RGS21
Regulator of G-protein signaling 21
Also known as: RGS21_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q2M5E4
- Gene
- RGS21
- Ensembl
- ENSG00000253148
- Chromosome
- 1
- Canonical length
- 152 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins are GTPase-activating proteins for Gi (see GNAI1; MIM 139310) and Gq (see GNAQ; MIM 600998) class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination.[supplied by OMIM, Nov 2008]
Canonical amino-acid sequenceUniProt
152 residues, UniProt reviewed canonical sequence.
>Q2M5E4|RGS21
1 MPVKCCFYRS PTAETMTWSE NMDTLLANQA GLDAFRIFLK SEFSEENVEF WLACEDFKKT
61 KNADKIASKA KMIYSEFIEA DAPKEINIDF GTRDLISKNI AEPTLKCFDE AQKLIYCLMA
121 KDSFPRFLKS EIYKKLVNSQ QVPNHKKWLP FLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against RGS21 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.37
- Highest tissue expression
- 0 nTPM
Expression across tissuesHPA
Tissue
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
- basal ganglia: 0 nTPM
- blood vessel: 0 nTPM
Single-cell type
- müller glia: 17 nCPM
- retinal ganglion cells: 7.7 nCPM
- respiratory ciliated cells: 7.2 nCPM
- cardiomyocytes: 5.6 nCPM
- mast cells: 4.4 nCPM
- thymic myoid cells: 4.1 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- medulla oblongata: 0.3 nTPM
- spinal cord: 0.3 nTPM
- white matter: 0.3 nTPM
- midbrain: 0.2 nTPM
- amygdala: 0.1 nTPM
- cerebral cortex: 0.1 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.65
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.36
- DepMap mean gene effect
- 0.03
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- G protein-coupled receptor signaling pathway
- negative regulation of signal transduction
- sensory perception of bitter taste
- sensory perception of sweet taste
- sensory perception of umami taste
- transmission of nerve impulse
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads RGS21 as an antibody target. Whether an autoantibody or antibody against RGS21 could matter depends on whether native RGS21 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
RGS21 is annotated at the cell surface, where native RGS21 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label RGS21 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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