Seroatlas · Human Serome Atlas

RGPD4

RanBP2-like and GRIP domain-containing protein 4

Also known as: DKFZp686P0288, RGP4, RGPD4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z3J3
Gene: RGPD4
Ensembl: ENSG00000196862
Chromosome: 2
Canonical length: 1758 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear membrane,Vesicles

OverviewNCBI Gene

Predicted to contribute to GTPase activator activity. Predicted to be involved in NLS-bearing protein import into nucleus. Predicted to be part of nuclear pore. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1758 residues, UniProt reviewed canonical sequence.

>Q7Z3J3|RGPD4
     1  MSCSKAYGER YVASVQGSAP SPRKKSTRGF YFAKLYYEAK EYDLAKKYIC TYINVREMDP
    61  RAHRFLGLLY ELEENTEKAV ECYRRSVELN PTQKDLVLKI AELLCKNDVT DGRAKYWVER
   121  AAKLFPGSPA IYKLKEQLLD CEGEDGWNKL FDLIQSELYV RPDDVHVNIR LVELYRSTKR
   181  LKDAVARCHE AERNIALRSS LEWNSCVVQT LKEYLESLQC LESDKSDWRA TNTDLLLAYA
   241  NLMLLTLSTR DVQESRELLE SFDSALQSAK SSLGGNDELS ATFLEMKGHF YMHAGSLLLK
   301  MGQHGNNVQW RALSELAALC YLIAFQVPRP KIKLIKGEAG QNLLEMMACD RLSQSGHMLL
   361  NLSRGKQDFL KVVVETFANK SGQSALYDAL FSSQSPKDTS FLGSDDIGNI DVQEPELEDL
   421  ARYDVGAIRA HNGSLQHLTW LGLQWNSLPA LPGIRKWLKQ LFHHLPQETS RLETNAPESI
   481  CILDLEVFLL GVVYTSHLQL KEKCNSHHSS YQPLCLPLPV CKQLCTERQK SWWDAVCTLI
   541  HRKAVPGNSA KLRLLVQHEI NTLRAQEKHG LQPALLVHWA KCLQKMGSGL NSFYDQREYI
   601  GRSVHYWKKV LPLLKIIKKK NSIPEPIDPL FKHFHSVDIQ ASEIVEYEED AHVTFAILDA
   661  VNGNIEDAMT AFESIKSVVS YWNLALIFHR KAEDIANDAL SPEEQEECKN YLRKTRGYLI
   721  KILDDSDSNL SVVKKLPVPL ESVKEMLKSV MQELENYSEG DPLYKNGSLR NADSEIKHST
   781  PSPTKYSLSP SKSYKYSPKT PPRWAEDQNS LLKMIRQEVK AIKEEMQELK LNSSKSASHH
   841  RWPTENYGPD SVPDGYQGSQ TFHGAPLTVA TTGPSVYYSQ SPAYNSQYLL RPAANVTPTK
   901  GSSNTEFKST KEGFSIPVSA DGFKFGISEP GNQEKESEKP LENDTGFQAQ DISGQKNGRG
   961  VIFGQTSSTF TFADVAKSTS GEGFQFGKKD PNFKGFSGAG EKLFSSQCGK MANKANTSGD
  1021  FEKDDDAYKT EDSDDIHFEP VVQMPEKVEL VIGEEGEKVL YSQGVKLFRF DAEVRQWKER
  1081  GLGNLKILKN EVNGKPRMLM RREQVLKVCA NHWITTTMNL KPLSGSDRAW MWSASDFSDG
  1141  DAKLERLAAK FKTPELAEEF KQKFEECQQL LLDIPLQTPH KLVDTGRAAK LIQRAEEMKS
  1201  GLKDFKTFLT NDQTKVTEEE NKGSGTGAAG ASDTTIKPNP ENTGPTLEWD NCDLREDALD
  1261  DSVSSSSVHA SPLASSPVRK NLFHFGESTT GSNFSFKSAL SPSKSPAKLN QSGTSVGTDE
  1321  ESDVTQEEER DGQYFEPVVP LPDLVEVSSG EENEKVVFSH RAELYRYDKD VGQWKERGIG
  1381  DIKILQNYDN KQVRIVMRRD QVLKLCANHT ITPDMSLQNM KGTERVWVWT ACDFADGERK
  1441  VEHLAVRFKL QDVADSFKKI FDEAKTAQEK DSLITPHVSR SSTPRESPCG KIAVAVLEET
  1501  TRERTDVIQG DDVADAASEV EVSSTSETTT KAVVSPPKFV FGSESVKRIF SSEKSKPFAF
  1561  GNSSATGSLF GFSFNASLKS NNSETSSVAQ SGSESKVEPK KCELSKNSDI EQSSDSKVKN
  1621  LSASFPMEES SINYTFKTPE KEPPLWHAEF TKEELVQKLS STTKSADHLN GLLREAEATS
  1681  AVLMEQIKLL KSEIRRLERN QEQEESAANV EHLKNVLLQF IFLKPGSERE RLLPVINTML
  1741  QLSPEEKGKL AAVAQGEE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RGPD4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 2.9 nTPM

Expression across tissuesHPA

Tissue

testis: 2.9 nTPM
retina: 1 nTPM
epididymis: 0.8 nTPM
pituitary gland: 0.6 nTPM
basal ganglia: 0.5 nTPM
cerebral cortex: 0.5 nTPM

Single-cell type

early spermatids: 21 nCPM
late primary spermatocytes: 17 nCPM
adrenal medulla cells: 11 nCPM
retinal bipolar cells: 8.9 nCPM
early primary spermatocytes: 5.8 nCPM
retinal ganglion cells: 3.9 nCPM

Immune cell

T-reg: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

thalamus: 1.3 nTPM
choroid plexus: 0.8 nTPM
midbrain: 0.8 nTPM
amygdala: 0.7 nTPM
cerebral cortex: 0.7 nTPM
basal ganglia: 0.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.9
gnomAD pLI: 0
gnomAD missense Z: -3.75
DepMap mean gene effect: -0.31
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

NLS-bearing protein import into nucleus

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RGPD4 as an antibody target. Whether an autoantibody or antibody against RGPD4 could matter depends on whether native RGPD4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RGPD4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RGPD4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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