Seroatlas · Human Serome Atlas

RGPD2

RANBP2-like and GRIP domain-containing protein 2

Also known as: RANBP2L2, RGP2, RGPD2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0DJD1
Gene: RGPD2
Ensembl: ENSG00000185304
Chromosome: 2
Canonical length: 1756 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear membrane,Vesicles

OverviewNCBI Gene

Predicted to contribute to GTPase activator activity. Predicted to be involved in NLS-bearing protein import into nucleus. Predicted to be part of nuclear pore. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1756 residues, UniProt reviewed canonical sequence.

>P0DJD1|RGPD2
     1  MRRSKAYGER YLASVQGSAP SPGKKLRGFY FAKLYYEAKE YDLAKKYVCT YLSVQERDPR
    61  AHRFLGLLYE LEENTEKAVE CYRRSLELNP PQKDLVLKIA ELLCKNDVTD GRAKYWVERA
   121  AKLFPGSPAI YKLKEHLLDC EGEDGWNKLF DWIQSELYVR PDDVHMNIRL VELYRSNKRL
   181  KDAVARCHEA ERNIALRSSL EWNSCVVQTL KEYLESLQCL ESDKSDWRAT NTDLLLAYAN
   241  LMLLTLSTRD VQESRELLES FDSALQSAKS SLGGNDELSA TFLEMKGHFY MHAGSLLLKM
   301  GQHGNNVQWQ ALSELAALCY VIAFQVPRPK IKLIKGEAGQ NLLEMMACDR LSQSGHMLLN
   361  LSRGKQDFLK EVVETFANKS GQSVLYNALF SSQSSKDTSF LGSDDIGNID VQEPELEDLA
   421  RYDVGAIQAH NGSLQHLTWL GLQWNSLPAL PGIRKWLKQL FHHLPQETSR LETNAPESIC
   481  ILDLEVFLLG VVYTSHLQLK EKCNSHHSSY QPLCLPLPVC KRLCTERQKS WWDAVCTLIH
   541  RKAVPGNSAE LRLVVQHEIN TLRAQEKHGL QPALLVHWAK CLQKMGRGLN SSYDQQEYIG
   601  RSVHYWKKVL PLLKIIKKNS IPEPIDPLFK HFHSVDIQAS EIVEYEEDAH ITFAILDAVH
   661  GNIEDAVTAF ESIKSVVSYW NLALIFHRKA EDIENDAVFP EEQEECKNYL RKTRDYLIKI
   721  IDDSDSNLSV VKKLPVPLES VKEMLKSVMQ ELEDYSEGGP LYKNGSLRNA DSEIKHSTPS
   781  PTKYSLSPSK SYKYSPKTPP RWAEDQNSLR KMICQEVKAI TKLNSSKSAS RHRWPTENYG
   841  PDSVPDGYQG SQTFHGAPLT VATTGPSVYY SQSPAYNSQY LLRPAANVTP TKGSSNTEFK
   901  STKEGFSIAV SADGFKFGIS EPGNQEKKSE KPLENDTGFQ AQDISGQKNG RGVIFGQTSS
   961  TFTFADVAKS TSGEGFQFGK KDPNFKGFSG AGEKLFSSQC GKMANKANTS GDFEKDDDAC
  1021  KTEDSDDIHF EPVVQMPEKV ELVTGEEGEK VLYSQGVKLF RFDAEISQWK ERGLGNLKIL
  1081  KNEVNGKPRM LMRRDQVLKV CANHWITTTM NLKPLSGSDR AWMWLASDFS DGDAKLERLA
  1141  AQFKTPELAE EFKQKFEECQ RLLLDIPLQT PHKLVDTGRA AKLIQRAEEM KSGLKDFKTF
  1201  LTNDQTKVTE EENKGSGTGA AGASDTTIKP NPENTGPTLE WDNYDLREDA LDDNVSSSSV
  1261  HDSPLASSPV RKNIFRFDES TTGFNFSFKS ALSLSKSPAK LNQSGTSVGT DEESDVTQEE
  1321  ERDGQYFEPV VPLPDLVEVS SGEENEQVVF SHMAELYRYD KDVGQWKERG IGDIKILQNY
  1381  DNKQVRIVMR RDQVLKLCAN HRITPDMSLQ NMKGTERVWV WTACDFADGE RKVEHLAVRF
  1441  KLQDVADSFK KIFDEAKTAQ EKDSLITPHV SRSSTPRESP CGKIAVAVLE ETTRERTDVI
  1501  QGDDVADAAS EVEVSSTSET TTKAVVSPPK FVFGSESVKR IFSSEKSNPF AFGNSSATGS
  1561  LFGFSFNAPL KSNDSETSSV AQSGSESKVE PKKCELSKNS DIEQSSDSKV KNLSASFPME
  1621  ESSINYTFKT PEKEPPLWHA EFTKEELVQK LSSTTKSADQ LNGLLRETEA TSAVLMEQIK
  1681  LLKSEIRRLE RNQEESAANV EHLKNVLLQF IFLKPGSERE SLLPVINTML QLSPEEKGKL
  1741  AAVAQGLQET SIPKKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RGPD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

testis: 14 nTPM
liver: 11 nTPM
placenta: 5.8 nTPM
pituitary gland: 5.7 nTPM
cervix: 5.6 nTPM
pancreas: 5.4 nTPM

Single-cell type

syncytiotrophoblasts: 57 nCPM
pancreatic acinar cells: 39 nCPM
extravillous trophoblasts: 32 nCPM
epicardial cells: 23 nCPM
pdcs: 22 nCPM
cardiomyocytes: 22 nCPM

Immune cell

T-reg: 9.8 nTPM
memory CD4 T-cell: 2 nTPM
naive CD4 T-cell: 0.9 nTPM
memory B-cell: 0.3 nTPM
memory CD8 T-cell: 0.3 nTPM
naive B-cell: 0.3 nTPM

Brain region

cerebellum: 6 nTPM
choroid plexus: 4.6 nTPM
cerebral cortex: 4.3 nTPM
pons: 3.9 nTPM
amygdala: 3.4 nTPM
medulla oblongata: 3.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.47
gnomAD pLI: 0
gnomAD missense Z: -0.03

OntologyGO

Biological processes

NLS-bearing protein import into nucleus

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RGPD2 as an antibody target. Whether an autoantibody or antibody against RGPD2 could matter depends on whether native RGPD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RGPD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RGPD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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