Seroatlas · Human Serome Atlas

RGPD1

RANBP2-like and GRIP domain-containing protein 1

Also known as: RGPD1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0DJD0
Gene
RGPD1
Canonical length
1748 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for RGPD1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

1748 residues, UniProt reviewed canonical sequence.

>P0DJD0|RGPD1
     1  MNVMGFNTDR LAWTRNKLRG FYFAKLYYEA KEYDLAKKYV CTYLSVQERD PRAHRFLGLL
    61  YELEENTEKA VECYRRSLEL NPPQKDLVLK IAELLCKNDV TDGRAKYWVE RAAKLFPGSP
   121  AIYKLKEHLL DCEGEDGWNK LFDWIQSELY VRPDDVHMNI RLVELYRSNK RLKDAVARCH
   181  EAERNIALRS SLEWNSCVVQ TLKEYLESLQ CLESDKSDWR ATNTDLLLAY ANLMLLTLST
   241  RDVQESRELL ESFDSALQSA KSSLGGNDEL SATFLEMKGH FYMHAGSLLL KMGQHGNNVQ
   301  WQALSELAAL CYVIAFQVPR PKIKLIKGEA GQNLLEMMAC DRLSQSGHML LNLSRGKQDF
   361  LKEVVETFAN KSGQSVLYNA LFSSQSSKDT SFLGSDDIGN IDVQEPELED LARYDVGAIQ
   421  AHNGSLQHLT WLGLQWNSLP ALPGIRKWLK QLFHHLPQET SRLETNAPES ICILDLEVFL
   481  LGVVYTSHLQ LKEKCNSHHS SYQPLCLPLP VCKRLCTERQ KSWWDAVCTL IHRKAVPGNS
   541  AELRLVVQHE INTLRAQEKH GLQPALLVHW AKCLQKMGRG LNSSYDQQEY IGRSVHYWKK
   601  VLPLLKIIKK NSIPEPIDPL FKHFHSVDIQ ASEIVEYEED AHITFAILDA VHGNIEDAVT
   661  AFESIKSVVS YWNLALIFHR KAEDIENDAV FPEEQEECKN YLRKTRDYLI KIIDDSDSNL
   721  SVVKKLPVPL ESVKEMLKSV MQELEDYSEG GPLYKNGSLR NADSEIKHST PSPTKYSLSP
   781  SKSYKYSPKT PPRWAEDQNS LRKMICQEVK AITKLNSSKS ASRHRWPTEN YGPDSVPDGY
   841  QGSQTFHGAP LTVATTGPSV YYSQSPAYNS QYLLRPAANV TPTKGSSNTE FKSTKEGFSI
   901  AVSADGFKFG ISEPGNQEKK SEKPLENDTG FQAQDISGQK NGRGVIFGQT SSTFTFADVA
   961  KSTSGEGFQF GKKDPNFKGF SGAGEKLFSS QCGKMANKAN TSGDFEKDDD ACKTEDSDDI
  1021  HFEPVVQMPE KVELVTGEEG EKVLYSQGVK LFRFDAEISQ WKERGLGNLK ILKNEVNGKP
  1081  RMLMRRDQVL KVCANHWITT TMNLKPLSGS DRAWMWLASD FSDGDAKLER LAAQFKTPEL
  1141  AEEFKQKFEE CQRLLLDIPL QTPHKLVDTG RAAKLIQRAE EMKSGLKDFK TFLTNDQTKV
  1201  TEEENKGSGT GAAGASDTTI KPNPENTGPT LEWDNYDLRE DALDDNVSSS SVHDSPLASS
  1261  PVRKNIFRFD ESTTGFNFSF KSALSLSKSP AKLNQSGTSV GTDEESDVTQ EEERDGQYFE
  1321  PVVPLPDLVE VSSGEENEQV VFSHRAELYR YDKDVGQWKE RGIGDIKILQ NYDNKQVRIV
  1381  MRRDQVLKLC ANHRITPDMS LQNMKGTERV WVWTACDFAD GERKVEHLAV RFKLQDVADS
  1441  FKKIFDEAKT AQEKDSLITP HVSRSSTPRE SPCGKIAVAV LEETTRERTD VIQGDDVADA
  1501  ASEVEVSSTS ETTTKAVVSP PKFVFGSESV KRIFSSEKSN PFAFGNSSAT GSLFGFSFNA
  1561  PLKSNDSETS SVAQSGSESK VEPKKCELSK NSDIEQSSDS KVKNLSASFP MEESSINYTF
  1621  KTPEKEPPLW HAEFTKEELV QKLSSTTKSA DQLNGLLRET EATSAVLMEQ IKLLKSEIRR
  1681  LERNQEESAA NVEHLKNVLL QFIFLKPGSE RESLLPVINT MLQLSPEEKG KLAAVAQGLQ
  1741  ETSIPKKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RGPD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
23 nTPM

Expression across tissuesHPA

Tissue

  • testis: 23 nTPM
  • placenta: 9.2 nTPM
  • cervix: 8 nTPM
  • bone marrow: 3 nTPM
  • pancreas: 2 nTPM
  • retina: 1.6 nTPM

Single-cell type

  • syncytiotrophoblasts: 56 nCPM
  • extravillous trophoblasts: 52 nCPM
  • cytotrophoblasts: 48 nCPM
  • cardiomyocytes: 42 nCPM
  • early spermatids: 33 nCPM
  • migrating cytotrophoblasts: 27 nCPM

Immune cell

  • memory B-cell: 0.4 nTPM
  • naive B-cell: 0.3 nTPM
  • eosinophil: 0.2 nTPM
  • MAIT T-cell: 0.2 nTPM
  • naive CD8 T-cell: 0.2 nTPM
  • NK-cell: 0.1 nTPM

Brain region

  • pons: 7.1 nTPM
  • cerebellum: 4.9 nTPM
  • medulla oblongata: 3.4 nTPM
  • midbrain: 3.2 nTPM
  • hypothalamus: 3 nTPM
  • cerebral cortex: 2.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.37
gnomAD pLI
0.01
gnomAD missense Z
1.49

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RGPD1 as an antibody target. Whether an autoantibody or antibody against RGPD1 could matter depends on whether native RGPD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RGPD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RGPD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RGPD1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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