Seroatlas · Human Serome Atlas

RGL4

Ral-GDS-related protein

Also known as: RGDSR_HUMAN, Rgr

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IZJ4
Gene: RGL4
Ensembl: ENSG00000159496
Chromosome: 22
Canonical length: 473 aa
Protein class: Predicted intracellular proteins
Subcellular location: Centrosome
Secretome location: Intracellular and membrane

OverviewNCBI Gene

This oncogene encodes a protein similar to guanine nucleotide exchange factor Ral guanine dissociation stimulator. Increased expression of this gene leads to translocation of the encoded protein to the cell membrane. The encoded protein can activate several pathways, including the Ras-Raf-MEK-ERK cascade. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

473 residues, UniProt reviewed canonical sequence.

>Q8IZJ4|RGL4
     1  MRKLLTNLPA AAVLSAQVYS AVLQGLWEEN VCGTPGRTRV CTALLYGQVC PFQDSTDGLR
    61  TITSILFNWP PENTSVYYQP PQRSSFRIKL AFRNLSWPGL GLEDHQEIVL GQLVLPEPNE
   121  AKPDDPAPRP GQHALTMPAL EPAPPLLADL GPALEPESPA ALGPPGYLHS APGPAPAPGE
   181  GPPPGTVLEP QSAPESSCPC RGSVKNQPSE ELPDMTTFPP RLLAEQLTLM DAELFKKVVL
   241  HECLGCIWGQ GHLKGNEHMA PTVRATIAHF NRLTNCITTS CLGDHSMRAR DRARVVEHWI
   301  KVARECLSLN NFSSVHVIVS ALCSNPIGQL HKTWAGVSSK SMKELKELCK KDTAVKRDLL
   361  IKAGSFKVAT QERNPQRVQM RLRRQKKGVV PFLGDFLTEL QRLDSAIPDD LDGNTNKRSK
   421  EVRVLQEMQL LQVAAMNYRL RPLEKFVTYF TRMEQLSDKE SYKLSCQLEP ENP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RGL4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 150 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 150 nTPM
spleen: 20 nTPM
retina: 11 nTPM
lymph node: 11 nTPM
thymus: 7.8 nTPM
tonsil: 7.5 nTPM

Single-cell type

neutrophil progenitors: 327 nCPM
neutrophils: 237 nCPM
epicardial cells: 50 nCPM
cardiomyocytes: 37 nCPM
t-cells: 32 nCPM
late primary spermatocytes: 27 nCPM

Immune cell

neutrophil: 519 nTPM
eosinophil: 395 nTPM
T-reg: 115 nTPM
naive CD4 T-cell: 105 nTPM
basophil: 98 nTPM
naive CD8 T-cell: 94 nTPM

Brain region

cerebellum: 15 nTPM
cerebral cortex: 12 nTPM
pons: 12 nTPM
white matter: 11 nTPM
medulla oblongata: 10 nTPM
choroid plexus: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.31
gnomAD pLI: 0
gnomAD missense Z: -0.28
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Ras protein signal transduction

Molecular functions

guanyl-nucleotide exchange factor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RGL4 as an antibody target. Whether an autoantibody or antibody against RGL4 could matter depends on whether native RGL4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RGL4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RGL4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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