Seroatlas · Human Serome Atlas

RFTN2

Raftlin-2

Also known as: C2orf11, FLJ30574, Raftlin-2, RFTN2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q52LD8
Gene: RFTN2
Ensembl: ENSG00000162944
Chromosome: 2
Canonical length: 501 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane

OverviewNCBI Gene

Predicted to act upstream of or within dsRNA transport and response to exogenous dsRNA. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

501 residues, UniProt reviewed canonical sequence.

>Q52LD8|RFTN2
     1  MGCGLRKLED PDDSSPGKIF STLKRPQVET KTEFAYEYVL LDFTLQASSN PEVIKINSIL
    61  DIVTKVENYY LKGYIVGAIH PVIQPVGQRK HLPASYLYRV VLLRLKLSPK NSAAPSGQRR
   121  PRLVIEECPL TSEAQTNDAA KELIEKINVA AKRGMKFVGF ISQHYSPSKF CNGTNHDGDI
   181  ESMLHVRHGS DENCRSWNEG TLSGQSSESG IEEELHHESG QYQMEQNGSP TSSKSRKGEA
   241  SDNKLYTVFN AFDDDSTSWA YQEGILSMKV TRKGSVISTL DADWLELTTF YYKQGLSLID
   301  SFVFWETSKG EHLPKSLEGF FIYEEEGSGV PGSSRKGNDA IVVEQWTVIE GCEIKTDYGP
   361  LLHTLAEFGW LLTSVLPTPV LRHDSEGNLA TKQIVFLQRP VMWNSAAQTP DKKASRHIKG
   421  EDKNKATSRS IGLDTTSSQP AESRHLPEEC RLSPSRECWT KEGRLAQHNS FSGFSSSDNV
   481  LRELDDGQFD QEDGVTQVTC M

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RFTN2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 25 nTPM
spinal cord: 19 nTPM
midbrain: 15 nTPM
amygdala: 13 nTPM
hippocampal formation: 13 nTPM
basal ganglia: 12 nTPM

Single-cell type

late spermatids: 550 nCPM
oligodendrocytes: 506 nCPM
bergmann glia: 482 nCPM
oligodendrocyte progenitor cells: 324 nCPM
astrocytes: 255 nCPM
ependymal cells: 131 nCPM

Immune cell

MAIT T-cell: 0.4 nTPM
naive CD8 T-cell: 0.4 nTPM
neutrophil: 0.3 nTPM
basophil: 0.2 nTPM
gdT-cell: 0.2 nTPM
memory CD4 T-cell: 0.2 nTPM

Brain region

white matter: 152 nTPM
medulla oblongata: 111 nTPM
basal ganglia: 108 nTPM
spinal cord: 93 nTPM
cerebellum: 90 nTPM
midbrain: 84 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.84
gnomAD pLI: 0
gnomAD missense Z: 0.33
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RFTN2 as an antibody target. Whether an autoantibody or antibody against RFTN2 could matter depends on whether native RFTN2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RFTN2 is annotated at the cell surface, where native RFTN2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RFTN2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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