Seroatlas · Human Serome Atlas

RFPL3S

Putative protein RFPL3S

Also known as: RFL3S_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0C7P2
Gene: RFPL3S
Canonical length: 107 aa

OverviewNCBI Gene

No narrative summary is available for RFPL3S in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

107 residues, UniProt reviewed canonical sequence.

>P0C7P2|RFPL3S
     1  MQTDTSNLSA RSCRFCVMSP LRTLLRSSEM RRKLLAVSAS KVISTVKRKT SCSASGQKPT
    61  PCLSSTSKAQ ISPDFSFFNS VSSSKIKTFH EETSLFQIFI GMLCGNT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RFPL3S can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.35
gnomAD pLI: 0.09
gnomAD missense Z: 0.52

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RFPL3S as an antibody target. Whether an autoantibody or antibody against RFPL3S could matter depends on whether native RFPL3S is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RFPL3S is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RFPL3S as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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