Seroatlas · Human Serome Atlas

RFNG

Beta-1,3-N-acetylglucosaminyltransferase radical fringe

Also known as: RFNG_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y644
Gene: RFNG
Ensembl: ENSG00000169733
Chromosome: 17
Canonical length: 331 aa
Protein class: Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity. Predicted to be involved in regulation of Notch signaling pathway. Predicted to act upstream of or within positive regulation of Notch signaling pathway. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

331 residues, UniProt reviewed canonical sequence.

>Q9Y644|RFNG
     1  MSRARGALCR ACLALAAALA ALLLLPLPLP RAPAPARTPA PAPRAPPSRP AAPSLRPDDV
    61  FIAVKTTRKN HGPRLRLLLR TWISRARQQT FIFTDGDDPE LELQGGDRVI NTNCSAVRTR
   121  QALCCKMSVE YDKFIESGRK WFCHVDDDNY VNARSLLHLL SSFSPSQDVY LGRPSLDHPI
   181  EATERVQGGR TVTTVKFWFA TGGAGFCLSR GLALKMSPWA SLGSFMSTAE QVRLPDDCTV
   241  GYIVEGLLGA RLLHSPLFHS HLENLQRLPP DTLLQQVTLS HGGPENPHNV VNVAGGFSLH
   301  QDPTRFKSIH CLLYPDTDWC PRQKQGAPTS R

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RFNG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 73 nTPM

Expression across tissuesHPA

Tissue

liver: 73 nTPM
skeletal muscle: 42 nTPM
pancreas: 38 nTPM
blood vessel: 26 nTPM
ovary: 26 nTPM
adipose tissue: 25 nTPM

Single-cell type

breast lactating cells: 71 nCPM
hepatocytes: 54 nCPM
bergmann glia: 51 nCPM
astrocytes: 47 nCPM
epididymal principal cells: 45 nCPM
breast myoepithelial cells: 34 nCPM

Immune cell

T-reg: 2.5 nTPM
eosinophil: 2 nTPM
classical monocyte: 1.9 nTPM
gdT-cell: 1.7 nTPM
memory CD8 T-cell: 1.6 nTPM
myeloid DC: 1.4 nTPM

Brain region

medulla oblongata: 19 nTPM
amygdala: 18 nTPM
pons: 18 nTPM
basal ganglia: 17 nTPM
thalamus: 17 nTPM
midbrain: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.78
gnomAD pLI: 0
gnomAD missense Z: 0.23
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RFNG as an antibody target. Whether an autoantibody or antibody against RFNG could matter depends on whether native RFNG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RFNG is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RFNG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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